Spatiotemporal gene expression drives neurodevelopment. Therefore, abnormal expression during development results in atypical brain function. Alterations in gene expression have been described in autism spectrum disorder (ASD). Here, we focus on one aspect of gene expression, pre-mRNA splicing, specifically, the mechanism of its regulation by chromatin and how this is altered in ASD.
- autism spectrum disorder
- pre-mRNA splicing
- splicing regulation
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