The chromatin roots of abnormal splicing in autism

Eden Engal, Mai Baker, Maayan Salton

Research output: Contribution to journalShort surveypeer-review


Spatiotemporal gene expression drives neurodevelopment. Therefore, abnormal expression during development results in atypical brain function. Alterations in gene expression have been described in autism spectrum disorder (ASD). Here, we focus on one aspect of gene expression, pre-mRNA splicing, specifically, the mechanism of its regulation by chromatin and how this is altered in ASD.

Original languageEnglish
Pages (from-to)892-894
Number of pages3
JournalTrends in Genetics
Issue number9
StatePublished - Sep 2022


  • autism spectrum disorder
  • chromatin
  • pre-mRNA splicing
  • splicing regulation

All Science Journal Classification (ASJC) codes

  • Genetics


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