The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation

Elyad Lezmi; Uri Weissbein; Tamar Golan-Lev; Malka Nissim-Rafinia; Eran Meshorer; Nissim Benvenisty

doi:10.1016/j.stemcr.2020.05.014

The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation

Elyad Lezmi, Uri Weissbein, Tamar Golan-Lev, Malka Nissim-Rafinia, Eran Meshorer, Nissim Benvenisty

Department of Genetics

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.

Original language	English
Pages (from-to)	1275-1286
Number of pages	12
Journal	Stem Cell Reports
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.stemcr.2020.05.014
State	Published - 8 Dec 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

chromatin
differentiation
human pluripotent stem cells
naive cells
primed cells
teratoma

All Science Journal Classification (ASJC) codes

Biochemistry
Genetics
Developmental Biology
Cell Biology

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10.1016/j.stemcr.2020.05.014

Cite this

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title = "The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation",

abstract = "In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.",

keywords = "chromatin, differentiation, human pluripotent stem cells, naive cells, primed cells, teratoma",

author = "Elyad Lezmi and Uri Weissbein and Tamar Golan-Lev and Malka Nissim-Rafinia and Eran Meshorer and Nissim Benvenisty",

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doi = "10.1016/j.stemcr.2020.05.014",

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T1 - The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation

AU - Lezmi, Elyad

AU - Weissbein, Uri

AU - Golan-Lev, Tamar

AU - Nissim-Rafinia, Malka

AU - Meshorer, Eran

AU - Benvenisty, Nissim

PY - 2020/12/8

Y1 - 2020/12/8

N2 - In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.

AB - In this article Lezmi et al. identified the chromatin regulator, ZMYM2, as a major epigenetic factor involved in human ESCs growth, and showed that its loss causes adverse transcriptional and epigenetic changes. ZMYM2-null ESCs overexpress naive pluripotency genes while losing their capacity to properly differentiate in vitro and form teratomas in vivo.

KW - chromatin

KW - differentiation

KW - human pluripotent stem cells

KW - naive cells

KW - primed cells

KW - teratoma

UR - http://www.scopus.com/inward/record.url?scp=85096990158&partnerID=8YFLogxK

U2 - 10.1016/j.stemcr.2020.05.014

DO - 10.1016/j.stemcr.2020.05.014

M3 - مقالة

C2 - 32559458

SN - 2213-6711

VL - 15

SP - 1275

EP - 1286

JO - Stem Cell Reports

JF - Stem Cell Reports

IS - 6

ER -

The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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