The bacterial second messenger c-di-GMP: Mechanisms of signalling

Erez Mills, Ingrid S. Pultz, Hemantha D. Kulasekara, Samuel I. Miller

Research output: Contribution to journalShort surveypeer-review


Cyclic-di-GMP (c-di-GMP) regulates many important bacterial processes. Freely diffusible intracellular c-di-GMP is determined by the action of metabolizing enzymes that allow integration of numerous input signals. c-di-GMP specifically regulates multiple cellular processes by binding to diverse target molecules. This review highlights important questions in research into the mechanisms of c-di-GMP signalling and its role in bacterial physiology.

Original languageAmerican English
Pages (from-to)1122-1129
Number of pages8
JournalCellular Microbiology
Issue number8
StatePublished - Aug 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology


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