The association between hidradenitis suppurativa and male and female infertility: A population-based study

Dana Tzur Bitan, Khalaf Kridin, Emmilia Hodak, Arnon Cohen, Shany Sherman

Research output: Contribution to journalArticlepeer-review


Background: Endocrine and metabolic associations have been recently reported in patients with hidradenitis suppurativa (HS); however, fertility was only rarely investigated in women and not at all in men. Objective: To evaluate the association of HS with male and female infertility. Methods: A cross-sectional, matched controlled, population-based study was designed. The association between HS and male and female infertility was evaluated in patients with HS (n = 4191) and age- and gender-matched controls (n = 20 941), while utilising the Clalit Health Services databases, the largest community-based health maintenance organisation in Israel. Results: Hidradenitis suppurativa was associated with infertility in males and females over all reproductive-age groups, especially among individuals aged 36–45 years (OR 4.50, 95%CI 2.55–7.93, P < 0.001), and in female patients (OR 3.10, 95%CI 2.57–3.74, P < 0.001). After adjustment for demographic and clinical factors, the association remained significant only in females (OR 1.26 95%CI 1.04–1.55, P < 0.05). Conclusion: Patients with HS are at increased risk of infertility, particularly females and patients in the 36- to 45-year age group. Physicians should take the additional physiological and psychological burden of infertility among HS patients into account, primarily among female patients at procreative age.

Original languageAmerican English
Pages (from-to)e223-e227
JournalAustralasian Journal of Dermatology
Issue number2
StatePublished - 1 May 2021


  • Adult
  • Age Factors
  • Case-Control Studies
  • Cross-Sectional Studies
  • Diabetes Mellitus/epidemiology
  • Female
  • Hidradenitis Suppurativa/epidemiology
  • Humans
  • Infertility, Female/epidemiology
  • Infertility, Male/epidemiology
  • Israel/epidemiology
  • Male
  • Marital Status
  • Middle Aged
  • Obesity/epidemiology
  • Retrospective Studies
  • Smoking/epidemiology
  • Social Class
  • cohort
  • female infertility
  • hidradenitis suppurativa (HS)
  • male infertility

All Science Journal Classification (ASJC) codes

  • Dermatology


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