@article{a520352ff43a4c6ab36770f78e23961a,
title = "Targeting Metabolic Plasticity and flexibility Dynamics for Cancer Therapy",
abstract = "Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and survival while subject to changes in environmental cues. Thus, a vital component of a cancer cell lies in its metabolic adaptability. The constant demand for metabolic alterations requires flexibility, that is, the ability to utilize different metabolic substrates; as well as plasticity, that is, the ability to process metabolic substrates in different ways. In this review, we discuss how dynamic changes in cancer metabolism affect tumor progression and the consequential implications for cancer therapy. Significance: Recognizing cancer dynamic metabolic adaptability as an entity can lead to targeted therapy that is expected to decrease drug resistance.",
author = "Sarah-Maria Fendt and Christian Frezza and Ayelet Erez",
note = "We acknowledge and thank the Weizmann Institute for providing financial and infrastructural support. A. Erez is incumbent of the Leah Omenn Career Development Chair and is supported by research grants from the European research program (ERC818943) and from the Israel Science Foundation (860/18). A. Erez received additional support from The Moross Integrated Cancer Center, Sagol Institute for Longevity Research, Adelis Foundation, Rising Tide Foundation, and from Manya and Adolph Zarovinsky. C. Frezza's work is funded by the MRC Core award grant MRC_MC_UU_12022/6, the ERC (ERC819920), and CRUK Programme Foundation award C51061/A27453. S.-M. Fendt acknowledges funding from the ERC Consolidator Grant Agreement no. ERC771486, FWO – Research Projects (G098120N and G088318N), KU Leuven – Methusalem Co-Funding, and Fonds Baillet Latour.",
year = "2020",
month = dec,
doi = "https://doi.org/10.1158/2159-8290.CD-20-0844",
language = "الإنجليزيّة",
volume = "10",
pages = "1797--1807",
journal = "Cancer Discovery",
issn = "2159-8274",
publisher = "John Wiley and Sons Inc.",
number = "12",
}