Tackling myelin deficits in neurodevelopmental disorders using drug delivery systems

May Rokach, Corinne Portioli, Sayanti Brahmachari, Bianca Martins Estevão, Paolo Decuzzi, Boaz Barak

Research output: Contribution to journalReview articlepeer-review


Interest in myelin and its roles in almost all brain functions has been greatly increasing in recent years, leading to countless new studies on myelination, as a dominant process in the development of cognitive functions. Here, we explore the unique role myelin plays in the central nervous system and specifically discuss the results of altered myelination in neurodevelopmental disorders. We present parallel developmental trajectories involving myelination that correlate with the onset of cognitive impairment in neurodevelopmental disorders and discuss the key challenges in the treatment of these chronic disorders. Recent developments in drug repurposing and nano/micro particle-based therapies are reviewed as a possible pathway to circumvent some of the main hurdles associated with early intervention, including patient's adherence and compliance, side effects, relapse, and faster route to possible treatment of these disorders. The strategy of drug encapsulation overcomes drug solubility and metabolism, with the possibility of drug targeting to a specific compartment, reducing side effects upon systemic administration.

Original languageEnglish
Article number115218
JournalAdvanced Drug Delivery Reviews
StatePublished - Apr 2024


  • Autism
  • Drug delivery system
  • Drug repurposing
  • Myelin
  • Neurodevelopmental disorders
  • Oligodendrocyte
  • Pro-myelination drugs
  • Slow release
  • White matter

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science


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