TY - BOOK
T1 - Systems Medicine
T2 - Physiological Circuits and the Dynamics of Disease
AU - Alon, Uri
N1 - Publisher Copyright: © 2024 Uri Alon.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Why do we get certain diseases, whereas other diseases do not exist? In this book, Alon, one of the founders of systems biology, builds a foundation for systems medicine. Starting from basic laws, the book derives why physiological circuits are built the way they are. The circuits have fragilities that explain specific diseases and offer new strategies to treat them. By the end, the reader will be able to use simple and powerful mathematical models to describe physiological circuits. The book explores, in three parts, hormone circuits, immune circuits, and aging and age-related disease. It culminates in a periodic table of diseases. Alon writes in a style accessible to a broad range of readers - undergraduates, graduates, or researchers from computational or biological backgrounds. The level of math is friendly and the math can even be bypassed altogether. For instructors and readers who want to go deeper, the book includes dozens of exercises that have been rigorously tested in the classroom.
AB - Why do we get certain diseases, whereas other diseases do not exist? In this book, Alon, one of the founders of systems biology, builds a foundation for systems medicine. Starting from basic laws, the book derives why physiological circuits are built the way they are. The circuits have fragilities that explain specific diseases and offer new strategies to treat them. By the end, the reader will be able to use simple and powerful mathematical models to describe physiological circuits. The book explores, in three parts, hormone circuits, immune circuits, and aging and age-related disease. It culminates in a periodic table of diseases. Alon writes in a style accessible to a broad range of readers - undergraduates, graduates, or researchers from computational or biological backgrounds. The level of math is friendly and the math can even be bypassed altogether. For instructors and readers who want to go deeper, the book includes dozens of exercises that have been rigorously tested in the classroom.
UR - http://www.scopus.com/inward/record.url?scp=85176875166&partnerID=8YFLogxK
U2 - 10.1201/9781003356929
DO - 10.1201/9781003356929
M3 - Book
SN - 9781032412283
T3 - Chapman & Hall/CRC Computational Biology Series
BT - Systems Medicine
PB - CRC Press
ER -