Abstract
A general synthesis of phylogenetically and structurally different tricyclic angularly fused spiranoid lactones, frequently observed as scaffold segments of various biochemical compounds and drugs of natural origin, is demonstrated via controlled cyclization of simple and easily accessible cycloalkylmethylene key precursors. The rapid composition of the key architecture yields an assembly of stable bicyclic iodolactones, which are converted to form a wide range of angularly fused tricyclic scaffolds.
Original language | English |
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Pages (from-to) | 10464-10473 |
Number of pages | 10 |
Journal | Journal of Organic Chemistry |
Volume | 80 |
Issue number | 21 |
DOIs | |
State | Published - 6 Nov 2015 |
All Science Journal Classification (ASJC) codes
- Organic Chemistry