Abstract
Overcoming the inherent difficulty to prepare quaternary carbon stereogenic centers, the diastereo- and enantioselective preparation of acyclic carbon backbones possessing vicinal quaternary and tertiary stereogenic centers (i.e. in a 1,2-relationship) causes distorted geometries and represents a very acute problem in organic synthesis. Several approaches are discussed in this minireview underlining the challenges illustrated by the rather limited number of approaches available to practitioners.
| Original language | English |
|---|---|
| Pages (from-to) | 36-49 |
| Number of pages | 14 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 59 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2 Jan 2020 |
Keywords
- diastereodivergence
- quaternary stereogenic centers
- stereogenic centers
- tertiary stereogenic centers
- vicinal positions
All Science Journal Classification (ASJC) codes
- Catalysis
- General Chemistry