Abstract
Aminoglycosides (AGs) are broad-spectrum antibiotics commonly used for the treatment of serious bacterial infections. These antibacterial agents target the prokaryotic ribosome by binding to the decoding A-site of the 16S ribosomal RNA (rRNA) and interfering with the protein translation process [1-5]. Following the isolation of the first known AG, streptomycin, from Streptomyces griseus by Schatz and Waksman [6] in 1944, multiple natural AGs with high structural diversity have been discovered (Figure 1). All AGs are composed of one or more carbohydrate units and contain a single pseudo-sugar aminocyclitol ring.
| Original language | English |
|---|---|
| Title of host publication | Modern Synthetic Methods in Carbohydrate Chemistry |
| Subtitle of host publication | From Monosaccharides to Complex Glycoconjugates |
| Publisher | Wiley-VCH Verlag |
| Pages | 161-190 |
| Number of pages | 30 |
| ISBN (Electronic) | 9783527658947 |
| ISBN (Print) | 9783527332847 |
| DOIs | |
| State | Published - 18 Oct 2013 |
Keywords
- A-site targeting antibiotics
- Aminoglycoside antibiotics
- Aminoglycoside cationic amphiphiles
- Aminoglycoside read-through activity
- Aminoglycoside resistance
- Semisynthetic aminoglycosides
All Science Journal Classification (ASJC) codes
- General Chemistry
- General Chemical Engineering
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