Synthesis of a Zirconium Complex of an N, O-type p- tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

Varun Rawat; Arkadi Vigalok; Anshu Kumar Sinha; Garima Sachdeva; Chandra Mohan Srivastava; Gyandshwar K. Rao; Arun Kumar; Mandeep Singh; Komal Rathi; Ved Prakash Verma; Bhupender Yadav; Amit Kumar Pandey; Monika Vats

doi:10.1021/acsomega.2c03187

Synthesis of a Zirconium Complex of an N, O-type p- tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

Varun Rawat, Arkadi Vigalok, Anshu Kumar Sinha, Garima Sachdeva, Chandra Mohan Srivastava, Gyandshwar K. Rao, Arun Kumar, Mandeep Singh, Komal Rathi, Ved Prakash Verma, Bhupender Yadav, Amit Kumar Pandey, Monika Vats

School of Chemistry

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis and characterization of a new octahedral Zr(IV) complex of oxygen-depleted N,O-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies. The Zr metal lies at 2.091 Å from the plane of the calixarene ring. This complex has been utilized as an efficient catalyst for the synthesis of Biginelli adducts, bis(indolyl)methanes, and coumarins. This complex (Cl2Zr-calixarene) showed superior activity for these multicomponent reactions in comparison to the corresponding Ti(IV) and Zn(II) analogues. Ferrocene-appended bis(indolyl)methane, prepared using this catalyst, was also evaluated for its anticancer activity against the A-172 cell line.

Original language	English
Pages (from-to)	28471-28480
Number of pages	10
Journal	ACS Omega
Volume	7
Issue number	32
DOIs	https://doi.org/10.1021/acsomega.2c03187
State	Published - 16 Aug 2022

All Science Journal Classification (ASJC) codes

General Chemistry
General Chemical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsomega.2c03187

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Rawat, V., Vigalok, A., Sinha, A. K., Sachdeva, G., Srivastava, C. M., Rao, G. K., Kumar, A., Singh, M., Rathi, K., Verma, V. P., Yadav, B., Pandey, A. K., & Vats, M. (2022). Synthesis of a Zirconium Complex of an N, O-type p- tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions. ACS Omega, 7(32), 28471-28480. https://doi.org/10.1021/acsomega.2c03187

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title = "Synthesis of a Zirconium Complex of an N, O-type p- tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions",

abstract = "The synthesis and characterization of a new octahedral Zr(IV) complex of oxygen-depleted N,O-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies. The Zr metal lies at 2.091 {\AA} from the plane of the calixarene ring. This complex has been utilized as an efficient catalyst for the synthesis of Biginelli adducts, bis(indolyl)methanes, and coumarins. This complex (Cl2Zr-calixarene) showed superior activity for these multicomponent reactions in comparison to the corresponding Ti(IV) and Zn(II) analogues. Ferrocene-appended bis(indolyl)methane, prepared using this catalyst, was also evaluated for its anticancer activity against the A-172 cell line.",

author = "Varun Rawat and Arkadi Vigalok and Sinha, \{Anshu Kumar\} and Garima Sachdeva and Srivastava, \{Chandra Mohan\} and Rao, \{Gyandshwar K.\} and Arun Kumar and Mandeep Singh and Komal Rathi and Verma, \{Ved Prakash\} and Bhupender Yadav and Pandey, \{Amit Kumar\} and Monika Vats",

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month = aug,

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doi = "10.1021/acsomega.2c03187",

language = "الإنجليزيّة",

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T1 - Synthesis of a Zirconium Complex of an N, O-type p- tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

AU - Rawat, Varun

AU - Vigalok, Arkadi

AU - Sinha, Anshu Kumar

AU - Sachdeva, Garima

AU - Srivastava, Chandra Mohan

AU - Rao, Gyandshwar K.

AU - Kumar, Arun

AU - Singh, Mandeep

AU - Rathi, Komal

AU - Verma, Ved Prakash

AU - Yadav, Bhupender

AU - Pandey, Amit Kumar

AU - Vats, Monika

PY - 2022/8/16

Y1 - 2022/8/16

N2 - The synthesis and characterization of a new octahedral Zr(IV) complex of oxygen-depleted N,O-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies. The Zr metal lies at 2.091 Å from the plane of the calixarene ring. This complex has been utilized as an efficient catalyst for the synthesis of Biginelli adducts, bis(indolyl)methanes, and coumarins. This complex (Cl2Zr-calixarene) showed superior activity for these multicomponent reactions in comparison to the corresponding Ti(IV) and Zn(II) analogues. Ferrocene-appended bis(indolyl)methane, prepared using this catalyst, was also evaluated for its anticancer activity against the A-172 cell line.

AB - The synthesis and characterization of a new octahedral Zr(IV) complex of oxygen-depleted N,O-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies. The Zr metal lies at 2.091 Å from the plane of the calixarene ring. This complex has been utilized as an efficient catalyst for the synthesis of Biginelli adducts, bis(indolyl)methanes, and coumarins. This complex (Cl2Zr-calixarene) showed superior activity for these multicomponent reactions in comparison to the corresponding Ti(IV) and Zn(II) analogues. Ferrocene-appended bis(indolyl)methane, prepared using this catalyst, was also evaluated for its anticancer activity against the A-172 cell line.

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U2 - 10.1021/acsomega.2c03187

DO - 10.1021/acsomega.2c03187

M3 - مقالة

C2 - 35990458

SN - 2470-1343

VL - 7

SP - 28471

EP - 28480

JO - ACS Omega

JF - ACS Omega

IS - 32

ER -

Synthesis of a Zirconium Complex of an N, O-type p- tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

Abstract

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