Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

P. Shaul; R. I. Benhamou; I. M. Herzog; S. Louzoun Zada; Y. Ebenstein; M. Fridman

doi:10.1039/c6ob00031b

Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

P. Shaul, R. I. Benhamou, I. M. Herzog, S. Louzoun Zada, Y. Ebenstein, M. Fridman

School of Chemistry

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Cationic amphiphiles derived from trehalose have been synthesized; trehalose analogues substituted with n-pentyl or n-hexyl ethers exhibited membrane disrupting activities against clinically important Gram positive and Gram negative bacteria and fungi. Our results demonstrate that trehalose is a useful disaccharide scaffold for the development of broad-spectrum antimicrobial and antifungal agents.

Original language	English
Pages (from-to)	3012-3015
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	11
DOIs	https://doi.org/10.1039/c6ob00031b
State	Published - 2016

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1039/c6ob00031b

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abstract = "Cationic amphiphiles derived from trehalose have been synthesized; trehalose analogues substituted with n-pentyl or n-hexyl ethers exhibited membrane disrupting activities against clinically important Gram positive and Gram negative bacteria and fungi. Our results demonstrate that trehalose is a useful disaccharide scaffold for the development of broad-spectrum antimicrobial and antifungal agents.",

author = "P. Shaul and Benhamou, \{R. I.\} and Herzog, \{I. M.\} and \{Louzoun Zada\}, S. and Y. Ebenstein and M. Fridman",

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doi = "10.1039/c6ob00031b",

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AU - Herzog, I. M.

AU - Louzoun Zada, S.

AU - Ebenstein, Y.

AU - Fridman, M.

PY - 2016

Y1 - 2016

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AB - Cationic amphiphiles derived from trehalose have been synthesized; trehalose analogues substituted with n-pentyl or n-hexyl ethers exhibited membrane disrupting activities against clinically important Gram positive and Gram negative bacteria and fungi. Our results demonstrate that trehalose is a useful disaccharide scaffold for the development of broad-spectrum antimicrobial and antifungal agents.

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C2 - 26832956

SN - 1477-0520

VL - 14

SP - 3012

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

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ER -

Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

Abstract

All Science Journal Classification (ASJC) codes

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