Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration

Yongcheol Cho; Valentina Di Liberto; Dan Carlin; Kathy H. Li; Alma L. Burlingame; Shenheng Guan; Izhak Michaelevski; Valeria Cavalli

doi:https://doi.org/10.1074/jbc.M113.536607

Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration

Yongcheol Cho, Valentina Di Liberto, Dan Carlin, Kathy H. Li, Alma L. Burlingame, Shenheng Guan, Izhak Michaelevski, Valeria Cavalli

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Axon regeneration following nerve injury depends on activation of mTOR. Results: Nerve injury increases the expression of syntaxin13 in an mTOR-dependent manner. Conclusion: Injury-induced synthesis of syntaxin13 is important for axon regeneration. Significance: Learning which proteins are synthesized via mTOR in injured nerves is crucial to our understanding of regenerative mechanisms in peripheral neurons.

Original language	English
Pages (from-to)	15820-15832
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	22
DOIs	https://doi.org/10.1074/jbc.M113.536607
State	Published - 30 May 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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https://doi.org/10.1074/jbc.M113.536607

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title = "Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration",

abstract = "Background: Axon regeneration following nerve injury depends on activation of mTOR. Results: Nerve injury increases the expression of syntaxin13 in an mTOR-dependent manner. Conclusion: Injury-induced synthesis of syntaxin13 is important for axon regeneration. Significance: Learning which proteins are synthesized via mTOR in injured nerves is crucial to our understanding of regenerative mechanisms in peripheral neurons.",

author = "Yongcheol Cho and {Di Liberto}, Valentina and Dan Carlin and Li, {Kathy H.} and Burlingame, {Alma L.} and Shenheng Guan and Izhak Michaelevski and Valeria Cavalli",

year = "2014",

month = may,

day = "30",

doi = "https://doi.org/10.1074/jbc.M113.536607",

language = "الإنجليزيّة",

volume = "289",

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journal = "Journal of Biological Chemistry",

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T1 - Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration

AU - Cho, Yongcheol

AU - Di Liberto, Valentina

AU - Carlin, Dan

AU - Li, Kathy H.

AU - Burlingame, Alma L.

AU - Guan, Shenheng

AU - Michaelevski, Izhak

AU - Cavalli, Valeria

PY - 2014/5/30

Y1 - 2014/5/30

N2 - Background: Axon regeneration following nerve injury depends on activation of mTOR. Results: Nerve injury increases the expression of syntaxin13 in an mTOR-dependent manner. Conclusion: Injury-induced synthesis of syntaxin13 is important for axon regeneration. Significance: Learning which proteins are synthesized via mTOR in injured nerves is crucial to our understanding of regenerative mechanisms in peripheral neurons.

AB - Background: Axon regeneration following nerve injury depends on activation of mTOR. Results: Nerve injury increases the expression of syntaxin13 in an mTOR-dependent manner. Conclusion: Injury-induced synthesis of syntaxin13 is important for axon regeneration. Significance: Learning which proteins are synthesized via mTOR in injured nerves is crucial to our understanding of regenerative mechanisms in peripheral neurons.

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U2 - https://doi.org/10.1074/jbc.M113.536607

DO - https://doi.org/10.1074/jbc.M113.536607

M3 - مقالة

C2 - 24737317

SN - 0021-9258

VL - 289

SP - 15820

EP - 15832

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 22

ER -

Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration

Abstract

All Science Journal Classification (ASJC) codes

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