TY - JOUR
T1 - Synapsins regulate α-synuclein functions
AU - Atias, Merav
AU - Tevet, Yaara
AU - Sun, Jichao
AU - Stavsky, Alexandra
AU - Tal, Shani
AU - Kahn, Joy
AU - Roy, Subhojit
AU - Gitler, Daniel
N1 - Funding Information: ACKNOWLEDGMENTS. This work was funded by Israel Science Foundation Grant 1427/12 (to D.G.) and NIH/National Institute on Aging Grants P50AG005131 and R01AG048218 (to S.R.). Publisher Copyright: © 2019 National Academy of Sciences. All rights reserved.
PY - 2019/6/4
Y1 - 2019/6/4
N2 - The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.
AB - The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.
KW - Alpha synuclein
KW - Neurotransmission
KW - Synapsin
UR - http://www.scopus.com/inward/record.url?scp=85066626058&partnerID=8YFLogxK
U2 - https://doi.org/10.1073/pnas.1903054116
DO - https://doi.org/10.1073/pnas.1903054116
M3 - Article
C2 - 31110014
SN - 0027-8424
VL - 166
SP - 11116
EP - 11118
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 23
ER -