Synapsin E-domain is essential for α-synuclein function

Alexandra Stavsky, Leonardo A. Parra-Rivas, Shani Tal, Jen Riba, Kayalvizhi Madhivanan, Subhojit Roy, Daniel Gitler

Research output: Contribution to journalArticlepeer-review

Abstract

The cytosolic proteins synucleins and synapsins are thought to play cooperative roles in regulating synaptic vesicle (SV) recycling, but mechanistic insight is lacking. Here, we identify the synapsin E-domain as an essential functional binding-partner of α-synuclein (α-syn). Synapsin E-domain allows α-syn functionality, binds to α-syn, and is necessary and sufficient for enabling effects of α-syn at synapses of cultured mouse hippocampal neurons. Together with previous studies implicating the E-domain in clustering SVs, our experiments advocate a cooperative role for these two proteins in maintaining physiologic SV clusters.

Original languageAmerican English
JournaleLife
Volume12
DOIs
StatePublished - 7 May 2024

Keywords

  • alpha-synuclein
  • cell biology
  • mouse
  • neuroscience
  • presynaptic
  • synapsin
  • synaptic terminals
  • synaptic transmission
  • synaptic vesicles

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology

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