Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Batya Isaacson; Ofer Mandelboim

doi:10.1016/j.cmet.2018.07.008

Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Batya Isaacson, Ofer Mandelboim

Department of Immunology and Cancer Research

The Hebrew University of Jerusalem

Research output: Contribution to journal › Short survey › peer-review

Abstract

Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype. Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype.

Original language	English
Pages (from-to)	183-184
Number of pages	2
Journal	Cell Metabolism
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.cmet.2018.07.008
State	Published - 7 Aug 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2018.07.008

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title = "Sweet Killers: NK Cells Need Glycolysis to Kill Tumors",

abstract = "Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype. Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype.",

author = "Batya Isaacson and Ofer Mandelboim",

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AB - Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype. Natural killer (NK) cells are cytotoxic innate lymphocytes that play a major role in the immune battle against cancer. In this issue of Cell Metabolism, Cong et al. (2018) demonstrate that progressing tumors reduce NK cell glycolytic capacity, which leads to reduced cytotoxicity and an overall dysfunctional NK phenotype.

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JO - Cell Metabolism

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IS - 2

ER -

Sweet Killers: NK Cells Need Glycolysis to Kill Tumors

Abstract

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