Suspensions of manganese-grafted nanodiamonds: Preparation, NMR, and MRI study

Alexander M. Panich; Moti Salti; Aleksandr E. Aleksenskii; Yuri V. Kulvelis; Anastasia Chizhikova; Alexander Ya Vul'; Alexander I. Shames

doi:10.1016/j.diamond.2022.109591

Suspensions of manganese-grafted nanodiamonds: Preparation, NMR, and MRI study

Alexander M. Panich, Moti Salti, Aleksandr E. Aleksenskii, Yuri V. Kulvelis, Anastasia Chizhikova, Alexander Ya Vul', Alexander I. Shames

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

We report on preparation, NMR and MRI study of suspensions of detonation nanodiamonds (DNDs) with manganese ions directly grafted to their surfaces, which are considered as novel contrast agents for MRI. We measured proton relaxation times, relaxivities and MRI images in aqueous and saline suspensions of manganese-grafted nanodiamonds, and those covered by polyvinylpyrrolidone, with different manganese concentrations. A comparison of the above parameters in Mn-grafted DNDs with those in the recently studied Gd-grafted DNDs and Dotarem, a contrast agent usually used in clinical practice, leads to a conclusion that Mn-grafted DNDs may serve as contrast agents for MRI.

Original language	American English
Article number	109591
Journal	Diamond and Related Materials
Volume	131
DOIs	https://doi.org/10.1016/j.diamond.2022.109591
State	Published - 1 Jan 2023

Keywords

Grafting
Magnetic resonance imaging (MRI)
Manganese
Nanodiamond
Nuclear magnetic resonance (NMR)

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Mechanical Engineering
Materials Chemistry
Electrical and Electronic Engineering

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10.1016/j.diamond.2022.109591

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title = "Suspensions of manganese-grafted nanodiamonds: Preparation, NMR, and MRI study",

abstract = "We report on preparation, NMR and MRI study of suspensions of detonation nanodiamonds (DNDs) with manganese ions directly grafted to their surfaces, which are considered as novel contrast agents for MRI. We measured proton relaxation times, relaxivities and MRI images in aqueous and saline suspensions of manganese-grafted nanodiamonds, and those covered by polyvinylpyrrolidone, with different manganese concentrations. A comparison of the above parameters in Mn-grafted DNDs with those in the recently studied Gd-grafted DNDs and Dotarem, a contrast agent usually used in clinical practice, leads to a conclusion that Mn-grafted DNDs may serve as contrast agents for MRI.",

keywords = "Grafting, Magnetic resonance imaging (MRI), Manganese, Nanodiamond, Nuclear magnetic resonance (NMR)",

author = "Panich, {Alexander M.} and Moti Salti and Aleksenskii, {Aleksandr E.} and Kulvelis, {Yuri V.} and Anastasia Chizhikova and Vul', {Alexander Ya} and Shames, {Alexander I.}",

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doi = "10.1016/j.diamond.2022.109591",

language = "American English",

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TY - JOUR

T1 - Suspensions of manganese-grafted nanodiamonds

T2 - Preparation, NMR, and MRI study

AU - Panich, Alexander M.

AU - Salti, Moti

AU - Aleksenskii, Aleksandr E.

AU - Kulvelis, Yuri V.

AU - Chizhikova, Anastasia

AU - Vul', Alexander Ya

AU - Shames, Alexander I.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - We report on preparation, NMR and MRI study of suspensions of detonation nanodiamonds (DNDs) with manganese ions directly grafted to their surfaces, which are considered as novel contrast agents for MRI. We measured proton relaxation times, relaxivities and MRI images in aqueous and saline suspensions of manganese-grafted nanodiamonds, and those covered by polyvinylpyrrolidone, with different manganese concentrations. A comparison of the above parameters in Mn-grafted DNDs with those in the recently studied Gd-grafted DNDs and Dotarem, a contrast agent usually used in clinical practice, leads to a conclusion that Mn-grafted DNDs may serve as contrast agents for MRI.

AB - We report on preparation, NMR and MRI study of suspensions of detonation nanodiamonds (DNDs) with manganese ions directly grafted to their surfaces, which are considered as novel contrast agents for MRI. We measured proton relaxation times, relaxivities and MRI images in aqueous and saline suspensions of manganese-grafted nanodiamonds, and those covered by polyvinylpyrrolidone, with different manganese concentrations. A comparison of the above parameters in Mn-grafted DNDs with those in the recently studied Gd-grafted DNDs and Dotarem, a contrast agent usually used in clinical practice, leads to a conclusion that Mn-grafted DNDs may serve as contrast agents for MRI.

KW - Grafting

KW - Magnetic resonance imaging (MRI)

KW - Manganese

KW - Nanodiamond

KW - Nuclear magnetic resonance (NMR)

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U2 - 10.1016/j.diamond.2022.109591

DO - 10.1016/j.diamond.2022.109591

M3 - Article

SN - 0925-9635

VL - 131

JO - Diamond and Related Materials

JF - Diamond and Related Materials

M1 - 109591

ER -

Suspensions of manganese-grafted nanodiamonds: Preparation, NMR, and MRI study

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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