Surface-modified protein nanospheres as potential antiviral agents

Dana Baram-Pinto; Michal Richman; Aharon Gedanken; Shai Rahimipour; Ronit Sarid

doi:10.1039/c2cc33448h

Surface-modified protein nanospheres as potential antiviral agents

Dana Baram-Pinto, Michal Richman, Aharon Gedanken, Shai Rahimipour, Ronit Sarid

Department of Chemistry

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.

Original language	English
Pages (from-to)	8359-8361
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	67
DOIs	https://doi.org/10.1039/c2cc33448h
State	Published - 28 Aug 2012

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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title = "Surface-modified protein nanospheres as potential antiviral agents",

abstract = "A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.",

author = "Dana Baram-Pinto and Michal Richman and Aharon Gedanken and Shai Rahimipour and Ronit Sarid",

year = "2012",

month = aug,

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doi = "10.1039/c2cc33448h",

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T1 - Surface-modified protein nanospheres as potential antiviral agents

AU - Baram-Pinto, Dana

AU - Richman, Michal

AU - Gedanken, Aharon

AU - Rahimipour, Shai

AU - Sarid, Ronit

PY - 2012/8/28

Y1 - 2012/8/28

N2 - A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.

AB - A novel application of surface-modified protein nanospheres as potential antiviral agents is illustrated. By using a single-step sonochemical process, bovine serum albumin nanospheres were generated, whose surface was covalently conjugated with mercaptoethane sulfonate to chemically and electrostatically mimic cellular heparan sulfate. The nanospheres effectively inhibited HSV-1 infection.

UR - http://www.scopus.com/inward/record.url?scp=84865463341&partnerID=8YFLogxK

U2 - 10.1039/c2cc33448h

DO - 10.1039/c2cc33448h

M3 - مقالة

C2 - 22798998

SN - 1359-7345

VL - 48

SP - 8359

EP - 8361

JO - Chemical Communications

JF - Chemical Communications

IS - 67

ER -

Surface-modified protein nanospheres as potential antiviral agents

Abstract

All Science Journal Classification (ASJC) codes

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