Surface engineered porous silicon-based nanostructures for cancer therapy

Adi Tzur-Balter; Naama Massad-Ivanir; Ester Segal

doi:10.1557/opl.2012.483

Surface engineered porous silicon-based nanostructures for cancer therapy

Adi Tzur-Balter, Naama Massad-Ivanir, Ester Segal

Technion - Israel Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In this work, nanostructured porous silicon (PSi) hosts, synthesized by electrochemical etching of Si, are designed to carry and release the anti cancer drug, mitoxantrone dihydrochloride (MTX). We study the effect of surface chemistry of the Si scaffold on its properties as a drug carrier. The freshly-etched PSi is modified by surface alkylation using thermal hydrosilylation with 1-dodecene. Fourier-transform infrared spectroscopy and nitrogen adsorption-desorption measurements are employed to characterize the PSi carriers after chemical modification. Both, drug loading efficiency and release kinetics are found to be significantly affected by surface chemistry of the PSi. In vitro cytotoxicity studies on human breast carcinoma (MDA-MB-231) cells show that the MTX released from the PSi hosts maintains its cytotoxic functionality.

Original language	English
Title of host publication	Nanofunctional Materials, Nanostructures and Nanodevices for Cancer Applications
Pages	31-36
Number of pages	6
DOIs	https://doi.org/10.1557/opl.2012.483
State	Published - 2012
Event	2011 MRS Fall Meeting - Boston, MA, United States Duration: 28 Nov 2011 → 2 Dec 2011

Publication series

Name	Materials Research Society Symposium Proceedings
Volume	1416

Conference

Conference	2011 MRS Fall Meeting
Country/Territory	United States
City	Boston, MA
Period	28/11/11 → 2/12/11

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering
General Materials Science

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10.1557/opl.2012.483

Cite this

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title = "Surface engineered porous silicon-based nanostructures for cancer therapy",

abstract = "In this work, nanostructured porous silicon (PSi) hosts, synthesized by electrochemical etching of Si, are designed to carry and release the anti cancer drug, mitoxantrone dihydrochloride (MTX). We study the effect of surface chemistry of the Si scaffold on its properties as a drug carrier. The freshly-etched PSi is modified by surface alkylation using thermal hydrosilylation with 1-dodecene. Fourier-transform infrared spectroscopy and nitrogen adsorption-desorption measurements are employed to characterize the PSi carriers after chemical modification. Both, drug loading efficiency and release kinetics are found to be significantly affected by surface chemistry of the PSi. In vitro cytotoxicity studies on human breast carcinoma (MDA-MB-231) cells show that the MTX released from the PSi hosts maintains its cytotoxic functionality.",

author = "Adi Tzur-Balter and Naama Massad-Ivanir and Ester Segal",

year = "2012",

doi = "10.1557/opl.2012.483",

language = "الإنجليزيّة",

isbn = "9781627482288",

series = "Materials Research Society Symposium Proceedings",

pages = "31--36",

booktitle = "Nanofunctional Materials, Nanostructures and Nanodevices for Cancer Applications",

note = "2011 MRS Fall Meeting ; Conference date: 28-11-2011 Through 02-12-2011",

}

Tzur-Balter, A, Massad-Ivanir, N & Segal, E 2012, Surface engineered porous silicon-based nanostructures for cancer therapy. in Nanofunctional Materials, Nanostructures and Nanodevices for Cancer Applications. Materials Research Society Symposium Proceedings, vol. 1416, pp. 31-36, 2011 MRS Fall Meeting, Boston, MA, United States, 28/11/11. https://doi.org/10.1557/opl.2012.483

Surface engineered porous silicon-based nanostructures for cancer therapy. / Tzur-Balter, Adi; Massad-Ivanir, Naama; Segal, Ester.
Nanofunctional Materials, Nanostructures and Nanodevices for Cancer Applications. 2012. p. 31-36 (Materials Research Society Symposium Proceedings; Vol. 1416).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Surface engineered porous silicon-based nanostructures for cancer therapy

AU - Tzur-Balter, Adi

AU - Massad-Ivanir, Naama

AU - Segal, Ester

PY - 2012

Y1 - 2012

N2 - In this work, nanostructured porous silicon (PSi) hosts, synthesized by electrochemical etching of Si, are designed to carry and release the anti cancer drug, mitoxantrone dihydrochloride (MTX). We study the effect of surface chemistry of the Si scaffold on its properties as a drug carrier. The freshly-etched PSi is modified by surface alkylation using thermal hydrosilylation with 1-dodecene. Fourier-transform infrared spectroscopy and nitrogen adsorption-desorption measurements are employed to characterize the PSi carriers after chemical modification. Both, drug loading efficiency and release kinetics are found to be significantly affected by surface chemistry of the PSi. In vitro cytotoxicity studies on human breast carcinoma (MDA-MB-231) cells show that the MTX released from the PSi hosts maintains its cytotoxic functionality.

AB - In this work, nanostructured porous silicon (PSi) hosts, synthesized by electrochemical etching of Si, are designed to carry and release the anti cancer drug, mitoxantrone dihydrochloride (MTX). We study the effect of surface chemistry of the Si scaffold on its properties as a drug carrier. The freshly-etched PSi is modified by surface alkylation using thermal hydrosilylation with 1-dodecene. Fourier-transform infrared spectroscopy and nitrogen adsorption-desorption measurements are employed to characterize the PSi carriers after chemical modification. Both, drug loading efficiency and release kinetics are found to be significantly affected by surface chemistry of the PSi. In vitro cytotoxicity studies on human breast carcinoma (MDA-MB-231) cells show that the MTX released from the PSi hosts maintains its cytotoxic functionality.

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M3 - منشور من مؤتمر

SN - 9781627482288

T3 - Materials Research Society Symposium Proceedings

SP - 31

EP - 36

BT - Nanofunctional Materials, Nanostructures and Nanodevices for Cancer Applications

T2 - 2011 MRS Fall Meeting

Y2 - 28 November 2011 through 2 December 2011

ER -

Surface engineered porous silicon-based nanostructures for cancer therapy

Abstract

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UN SDGs

All Science Journal Classification (ASJC) codes

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