Sulfation Pattern Dependent Iron(III) Mediated Interleukin-8 Glycan Binding

Francesco Brunori, Deepak Kumar Padhi, Israel Alshanski, Joanna Freyse, Jan Niklas Dürig, Anja Penk, Luigi Vaccaro, Mattan Hurevich, Jörg Rademann, Shlomo Yitzchaik

Research output: Contribution to journalArticlepeer-review

Abstract

Cytokines such as interleukin-8 activate the immune system during infection and interact with sulfated glycosaminoglycans with specific sulfation patterns. In some cases, these interactions are mediated by metal ion binding which can be used to tune surface-based glycan-protein interactions. We evaluated the effect of both hyaluronan sulfation degree and Fe3+ on interleukin-8 binding by electrochemical impedance spectroscopy and surface characterizations. Our results show that sulfation degree and metal ion interactions have a synergistic effect in tuning the electrochemical response of the glycated surfaces to the cytokine.

Original languageAmerican English
Article numbere202100552
JournalChemBioChem
Volume23
Issue number3
DOIs
StatePublished - 4 Feb 2022

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Biochemistry
  • Organic Chemistry

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