Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient

Diana Averbuch; Rifaat Safadi; Daniel Dar; Dana Wolf; Meir Cherniak; Rotem Sorek; Sharon Amit

doi:10.1097/INF.0000000000002090

Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient

Diana Averbuch, Rifaat Safadi, Daniel Dar, Dana Wolf, Meir Cherniak, Rotem Sorek, Sharon Amit

Department of Molecular Genetics

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

A signal transducer and activator of transcription-1-deficient patient presented with prolonged fever, cachexia, anemia, hypoalbuminemia and finally relapsing debilitating mycobacterial osteomyelitis while receiving a previously effective antimycobacterial treatment. Progression despite rigorous workup and multiple antibiotics prompted shotgun metagenomics revealing adenovirus in liver samples. Brincidofovir led to a complete, sustained clinical recovery, including osteomyelitis, probably attributed to reversal of adenovirus-induced immune dysregulation.

Original language	English
Pages (from-to)	297-299
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	38
Issue number	3
DOIs	https://doi.org/10.1097/INF.0000000000002090
State	Published - 1 Mar 2019

Keywords

STAT1 deficiency
adenovirus
brincidofovir
shotgun metagenomics

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

Access to Document

10.1097/INF.0000000000002090

Cite this

@article{19a8d4c6e33943ec9a18326c056dcc36,

title = "Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient",

abstract = "A signal transducer and activator of transcription-1-deficient patient presented with prolonged fever, cachexia, anemia, hypoalbuminemia and finally relapsing debilitating mycobacterial osteomyelitis while receiving a previously effective antimycobacterial treatment. Progression despite rigorous workup and multiple antibiotics prompted shotgun metagenomics revealing adenovirus in liver samples. Brincidofovir led to a complete, sustained clinical recovery, including osteomyelitis, probably attributed to reversal of adenovirus-induced immune dysregulation.",

keywords = "STAT1 deficiency, adenovirus, brincidofovir, shotgun metagenomics",

author = "Diana Averbuch and Rifaat Safadi and Daniel Dar and Dana Wolf and Meir Cherniak and Rotem Sorek and Sharon Amit",

year = "2019",

month = mar,

day = "1",

doi = "10.1097/INF.0000000000002090",

language = "الإنجليزيّة",

volume = "38",

pages = "297--299",

number = "3",

}

Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient. / Averbuch, Diana; Safadi, Rifaat; Dar, Daniel et al.
In: Pediatric Infectious Disease Journal, Vol. 38, No. 3, 01.03.2019, p. 297-299.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient

AU - Averbuch, Diana

AU - Safadi, Rifaat

AU - Dar, Daniel

AU - Wolf, Dana

AU - Cherniak, Meir

AU - Sorek, Rotem

AU - Amit, Sharon

PY - 2019/3/1

Y1 - 2019/3/1

N2 - A signal transducer and activator of transcription-1-deficient patient presented with prolonged fever, cachexia, anemia, hypoalbuminemia and finally relapsing debilitating mycobacterial osteomyelitis while receiving a previously effective antimycobacterial treatment. Progression despite rigorous workup and multiple antibiotics prompted shotgun metagenomics revealing adenovirus in liver samples. Brincidofovir led to a complete, sustained clinical recovery, including osteomyelitis, probably attributed to reversal of adenovirus-induced immune dysregulation.

AB - A signal transducer and activator of transcription-1-deficient patient presented with prolonged fever, cachexia, anemia, hypoalbuminemia and finally relapsing debilitating mycobacterial osteomyelitis while receiving a previously effective antimycobacterial treatment. Progression despite rigorous workup and multiple antibiotics prompted shotgun metagenomics revealing adenovirus in liver samples. Brincidofovir led to a complete, sustained clinical recovery, including osteomyelitis, probably attributed to reversal of adenovirus-induced immune dysregulation.

KW - STAT1 deficiency

KW - adenovirus

KW - brincidofovir

KW - shotgun metagenomics

UR - http://www.scopus.com/inward/record.url?scp=85061486592&partnerID=8YFLogxK

U2 - 10.1097/INF.0000000000002090

DO - 10.1097/INF.0000000000002090

M3 - مقالة

C2 - 29742642

SN - 0891-3668

VL - 38

SP - 297

EP - 299

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 3

ER -

Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this