Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin

Orit Weil-Ktorza; Nischay Rege; Shifra Lansky; Deborah E. Shalev; Gil Shoham; Michael A. Weiss; Norman Metanis

doi:10.1002/chem.201901974

Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin

Orit Weil-Ktorza, Nischay Rege, Shifra Lansky, Deborah E. Shalev, Gil Shoham, Michael A. Weiss, Norman Metanis

The Hebrew University of Jerusalem

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Invited for the cover of this issue are the groups of Norman Metanis at The Hebrew University of Jerusalem and Michael A. Weiss at the Indiana University School of Medicine. The image depicts a simple method for the preparation of new insulin analogues with a particular interest in more stable analogues with extended shelf life. Read the full text of the article at 10.1002/chem.201900892.

Original language	English
Pages (from-to)	8430
Number of pages	1
Journal	Chemistry - A European Journal
Volume	25
Issue number	36
DOIs	https://doi.org/10.1002/chem.201901974
State	Published - 26 Jun 2019

All Science Journal Classification (ASJC) codes

Catalysis
General Chemistry
Organic Chemistry

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10.1002/chem.201901974

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abstract = "Invited for the cover of this issue are the groups of Norman Metanis at The Hebrew University of Jerusalem and Michael A. Weiss at the Indiana University School of Medicine. The image depicts a simple method for the preparation of new insulin analogues with a particular interest in more stable analogues with extended shelf life. Read the full text of the article at 10.1002/chem.201900892.",

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AU - Lansky, Shifra

AU - Shalev, Deborah E.

AU - Shoham, Gil

AU - Weiss, Michael A.

AU - Metanis, Norman

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AB - Invited for the cover of this issue are the groups of Norman Metanis at The Hebrew University of Jerusalem and Michael A. Weiss at the Indiana University School of Medicine. The image depicts a simple method for the preparation of new insulin analogues with a particular interest in more stable analogues with extended shelf life. Read the full text of the article at 10.1002/chem.201900892.

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

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Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin

Abstract

All Science Journal Classification (ASJC) codes

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