Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex

Physics & Astronomy

• diphosphates 73%
• mutations 52%
• assembly 38%
• phosphates 15%
• dimers 13%
• proteins 12%
• crystal structure 11%
• synthesis 10%
• molecular dynamics 10%
• perturbation 10%
• causes 9%
• simulation 5%

Medicine & Life Sciences

• cis-prenyl transferase 92%
• dehydrodolichyl diphosphate synthetase 51%
• Nogo Receptors 25%
• Mutation 25%
• Dolichol Phosphates 14%
• Catalytic Domain 13%
• Dolichols 11%
• Retinitis Pigmentosa 9%
• Molecular Dynamics Simulation 8%
• Glycosylation 7%

Chemistry

• Dehydrodolichyl Diphosphate 100%
• Mutation 38%
• Dolichol Phosphate 27%
• Dolichol 23%
• Heterodimer 17%
• Tetramer 14%
• Molecular Dynamics 11%
• Simulation 9%
• Crystal Structure 7%
• Protein 6%