@article{657df983a3fe4d2989a224ee628619c8,
title = "Structural and functional properties of the membranotropic HIV-1 glycoprotein gp41 loop region are modulated by its intrinsic hydrophobic core",
abstract = "Background:HIV-1 infectivity is decreased by specific mutations that alter the hydrophobicity level in the HIV-1 gp41 loop core. Results:Antibody recognition, disulfide-bond formation, and lipid mixing of loop domain peptides are strongly affected by these mutations. Conclusion:The hydrophobic core maintains proper function and structure of the loop region. Significance:A better understanding of the membrane fusion mechanism of HIV and similar viruses is provided.",
author = "Jiayin Qiu and Avraham Ashkenazi and Shuwen Liu and Yechiel Shai",
note = "Israel Science Foundation [988/09]; Science region is the existence of a basic residue (Lys-601) at the center and Technology Planning Project of Guangdong Province, China [2011B050200006]; Oversea Study Program of Guangzhou Elite Project, ChinaThis work was supported by the Israel Science Foundation (988/09), Science region is the existence of a basic residue (Lys-601) at the center and Technology Planning Project of Guangdong Province, China (2011B050200006), and by the Oversea Study Program of Guangzhou Elite Project, China (a fellowship to J. Q.).",
year = "2013",
month = oct,
day = "4",
doi = "https://doi.org/10.1074/jbc.M113.496646",
language = "American English",
volume = "288",
pages = "29143--29150",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "40",
}