Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model

Einav Mayzlish-Gati; Dana Laufer; Christopher F. Grivas; Julia Shaknof; Amiram Sananes; Ariel Bier; Shani Ben-Harosh; Eduard Belausov; Michael D. Johnson; Emma Artuso; Oshrat Levi; Ola Genin; Cristina Prandi; Isam Khalaila; Mark Pines; Ronit I. Yarden; Yoram Kapulnik; Hinanit Koltai

doi:10.1080/15384047.2015.1070982

Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model

Einav Mayzlish-Gati, Dana Laufer, Christopher F. Grivas, Julia Shaknof, Amiram Sananes, Ariel Bier, Shani Ben-Harosh, Eduard Belausov, Michael D. Johnson, Emma Artuso, Oshrat Levi, Ola Genin, Cristina Prandi, Isam Khalaila, Mark Pines, Ronit I. Yarden, Yoram Kapulnik, Hinanit Koltai

Department of Biotechnology Engineering

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Strigolactones (SLs) are a novel class of plant hormones. Previously, we found that analogs of SLs induce growth arrest and apoptosis in breast cancer cell lines. These compounds also inhibited the growth of breast cancer stem cell enriched-mammospheres with increased potency. Furthermore, strigolactone analogs inhibited growth and survival of colon, lung, prostate, melanoma, osteosarcoma and leukemia cancer cell lines. To further examine the anti-cancer activity of SLs in vivo, we have examined their effects on growth and viability of MDA-MB-231 tumor xenografts model either alone or in combination with paclitaxel. We show that strigolactone act as new anti-cancer agents in inhibition of breast cancer in xenograft model. In addition we show that SLs affect the integrity of the microtubule network and therefore may inhibit the migratory phenotype of the highly invasive breast cancer cell lines that were examined.

Original language	American English
Pages (from-to)	1682-1688
Number of pages	7
Journal	Cancer Biology and Therapy
Volume	16
Issue number	11
DOIs	https://doi.org/10.1080/15384047.2015.1070982
State	Published - 30 Oct 2015

Keywords

breast cancer
cell motility, microtubule
plant hormone
strigolactone
xenograft

All Science Journal Classification (ASJC) codes

Molecular Medicine
Oncology
Cancer Research
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/15384047.2015.1070982

Cite this

Mayzlish-Gati, E., Laufer, D., Grivas, C. F., Shaknof, J., Sananes, A., Bier, A., Ben-Harosh, S., Belausov, E., Johnson, M. D., Artuso, E., Levi, O., Genin, O., Prandi, C., Khalaila, I., Pines, M., Yarden, R. I., Kapulnik, Y., & Koltai, H. (2015). Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model. Cancer Biology and Therapy, 16(11), 1682-1688. https://doi.org/10.1080/15384047.2015.1070982

@article{45698e3940cd4f09af1e4da893e37d0a,

title = "Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model",

abstract = "Strigolactones (SLs) are a novel class of plant hormones. Previously, we found that analogs of SLs induce growth arrest and apoptosis in breast cancer cell lines. These compounds also inhibited the growth of breast cancer stem cell enriched-mammospheres with increased potency. Furthermore, strigolactone analogs inhibited growth and survival of colon, lung, prostate, melanoma, osteosarcoma and leukemia cancer cell lines. To further examine the anti-cancer activity of SLs in vivo, we have examined their effects on growth and viability of MDA-MB-231 tumor xenografts model either alone or in combination with paclitaxel. We show that strigolactone act as new anti-cancer agents in inhibition of breast cancer in xenograft model. In addition we show that SLs affect the integrity of the microtubule network and therefore may inhibit the migratory phenotype of the highly invasive breast cancer cell lines that were examined.",

keywords = "breast cancer, cell motility, microtubule, plant hormone, strigolactone, xenograft",

author = "Einav Mayzlish-Gati and Dana Laufer and Grivas, {Christopher F.} and Julia Shaknof and Amiram Sananes and Ariel Bier and Shani Ben-Harosh and Eduard Belausov and Johnson, {Michael D.} and Emma Artuso and Oshrat Levi and Ola Genin and Cristina Prandi and Isam Khalaila and Mark Pines and Yarden, {Ronit I.} and Yoram Kapulnik and Hinanit Koltai",

note = "Publisher Copyright: {\textcopyright} 2015 Taylor & Francis Group, LLC.",

year = "2015",

month = oct,

day = "30",

doi = "10.1080/15384047.2015.1070982",

language = "American English",

volume = "16",

pages = "1682--1688",

journal = "Cancer Biology and Therapy",

issn = "1538-4047",

publisher = "Taylor and Francis Ltd.",

number = "11",

}

Mayzlish-Gati, E, Laufer, D, Grivas, CF, Shaknof, J, Sananes, A, Bier, A, Ben-Harosh, S, Belausov, E, Johnson, MD, Artuso, E, Levi, O, Genin, O, Prandi, C, Khalaila, I, Pines, M, Yarden, RI, Kapulnik, Y & Koltai, H 2015, 'Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model', Cancer Biology and Therapy, vol. 16, no. 11, pp. 1682-1688. https://doi.org/10.1080/15384047.2015.1070982

TY - JOUR

T1 - Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model

AU - Mayzlish-Gati, Einav

AU - Laufer, Dana

AU - Grivas, Christopher F.

AU - Shaknof, Julia

AU - Sananes, Amiram

AU - Bier, Ariel

AU - Ben-Harosh, Shani

AU - Belausov, Eduard

AU - Johnson, Michael D.

AU - Artuso, Emma

AU - Levi, Oshrat

AU - Genin, Ola

AU - Prandi, Cristina

AU - Khalaila, Isam

AU - Pines, Mark

AU - Yarden, Ronit I.

AU - Kapulnik, Yoram

AU - Koltai, Hinanit

PY - 2015/10/30

Y1 - 2015/10/30

N2 - Strigolactones (SLs) are a novel class of plant hormones. Previously, we found that analogs of SLs induce growth arrest and apoptosis in breast cancer cell lines. These compounds also inhibited the growth of breast cancer stem cell enriched-mammospheres with increased potency. Furthermore, strigolactone analogs inhibited growth and survival of colon, lung, prostate, melanoma, osteosarcoma and leukemia cancer cell lines. To further examine the anti-cancer activity of SLs in vivo, we have examined their effects on growth and viability of MDA-MB-231 tumor xenografts model either alone or in combination with paclitaxel. We show that strigolactone act as new anti-cancer agents in inhibition of breast cancer in xenograft model. In addition we show that SLs affect the integrity of the microtubule network and therefore may inhibit the migratory phenotype of the highly invasive breast cancer cell lines that were examined.

AB - Strigolactones (SLs) are a novel class of plant hormones. Previously, we found that analogs of SLs induce growth arrest and apoptosis in breast cancer cell lines. These compounds also inhibited the growth of breast cancer stem cell enriched-mammospheres with increased potency. Furthermore, strigolactone analogs inhibited growth and survival of colon, lung, prostate, melanoma, osteosarcoma and leukemia cancer cell lines. To further examine the anti-cancer activity of SLs in vivo, we have examined their effects on growth and viability of MDA-MB-231 tumor xenografts model either alone or in combination with paclitaxel. We show that strigolactone act as new anti-cancer agents in inhibition of breast cancer in xenograft model. In addition we show that SLs affect the integrity of the microtubule network and therefore may inhibit the migratory phenotype of the highly invasive breast cancer cell lines that were examined.

KW - breast cancer

KW - cell motility, microtubule

KW - plant hormone

KW - strigolactone

KW - xenograft

UR - http://www.scopus.com/inward/record.url?scp=84948578744&partnerID=8YFLogxK

U2 - 10.1080/15384047.2015.1070982

DO - 10.1080/15384047.2015.1070982

M3 - Article

C2 - 26192476

SN - 1538-4047

VL - 16

SP - 1682

EP - 1688

JO - Cancer Biology and Therapy

JF - Cancer Biology and Therapy

IS - 11

ER -

Strigolactone analogs act as new anti-cancer agents in inhibition of breast cancer in xenograft model

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this