Stretch-induced actomyosin contraction in epithelial tubes: Mechanotransduction pathways for tubular homeostasis

Kriti Sethi; Erin J. Cram; Ronen Zaidel-Bar

doi:https://doi.org/10.1016/j.semcdb.2017.05.014

Stretch-induced actomyosin contraction in epithelial tubes: Mechanotransduction pathways for tubular homeostasis

Kriti Sethi, Erin J. Cram, Ronen Zaidel-Bar

Cell and Developmental Biology

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

Abstract

Many tissues in our body have a tubular shape and are constantly exposed to various stresses. Luminal pressure imposes tension on the epithelial and myoepithelial or smooth muscle cells surrounding the lumen of the tubes. Contractile forces generated by actomyosin assemblies within these cells oppose the luminal pressure and must be calibrated to maintain tube diameter homeostasis and tissue integrity. In this review, we discuss mechanotransduction pathways that can lead from sensation of cell stretch to activation of actomyosin contractility, providing rapid mechanochemical feedback for proper tubular tissue function.

Original language	English
Pages (from-to)	146-152
Number of pages	7
Journal	Seminars in Cell and Developmental Biology
Volume	71
DOIs	https://doi.org/10.1016/j.semcdb.2017.05.014
State	Published - Nov 2017

Keywords

Calcium
Contractility
Epithelial tubes
Integrin signaling
Mechanotransduction
RhoA
Smooth muscle
Stretch

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

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https://doi.org/10.1016/j.semcdb.2017.05.014

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title = "Stretch-induced actomyosin contraction in epithelial tubes: Mechanotransduction pathways for tubular homeostasis",

abstract = "Many tissues in our body have a tubular shape and are constantly exposed to various stresses. Luminal pressure imposes tension on the epithelial and myoepithelial or smooth muscle cells surrounding the lumen of the tubes. Contractile forces generated by actomyosin assemblies within these cells oppose the luminal pressure and must be calibrated to maintain tube diameter homeostasis and tissue integrity. In this review, we discuss mechanotransduction pathways that can lead from sensation of cell stretch to activation of actomyosin contractility, providing rapid mechanochemical feedback for proper tubular tissue function.",

keywords = "Calcium, Contractility, Epithelial tubes, Integrin signaling, Mechanotransduction, RhoA, Smooth muscle, Stretch",

author = "Kriti Sethi and Cram, {Erin J.} and Ronen Zaidel-Bar",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2017",

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doi = "https://doi.org/10.1016/j.semcdb.2017.05.014",

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T1 - Stretch-induced actomyosin contraction in epithelial tubes

T2 - Mechanotransduction pathways for tubular homeostasis

AU - Sethi, Kriti

AU - Cram, Erin J.

AU - Zaidel-Bar, Ronen

PY - 2017/11

Y1 - 2017/11

N2 - Many tissues in our body have a tubular shape and are constantly exposed to various stresses. Luminal pressure imposes tension on the epithelial and myoepithelial or smooth muscle cells surrounding the lumen of the tubes. Contractile forces generated by actomyosin assemblies within these cells oppose the luminal pressure and must be calibrated to maintain tube diameter homeostasis and tissue integrity. In this review, we discuss mechanotransduction pathways that can lead from sensation of cell stretch to activation of actomyosin contractility, providing rapid mechanochemical feedback for proper tubular tissue function.

AB - Many tissues in our body have a tubular shape and are constantly exposed to various stresses. Luminal pressure imposes tension on the epithelial and myoepithelial or smooth muscle cells surrounding the lumen of the tubes. Contractile forces generated by actomyosin assemblies within these cells oppose the luminal pressure and must be calibrated to maintain tube diameter homeostasis and tissue integrity. In this review, we discuss mechanotransduction pathways that can lead from sensation of cell stretch to activation of actomyosin contractility, providing rapid mechanochemical feedback for proper tubular tissue function.

KW - Calcium

KW - Contractility

KW - Epithelial tubes

KW - Integrin signaling

KW - Mechanotransduction

KW - RhoA

KW - Smooth muscle

KW - Stretch

UR - http://www.scopus.com/inward/record.url?scp=85020933569&partnerID=8YFLogxK

U2 - https://doi.org/10.1016/j.semcdb.2017.05.014

DO - https://doi.org/10.1016/j.semcdb.2017.05.014

M3 - مقالة مرجعية

SN - 1084-9521

VL - 71

SP - 146

EP - 152

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -

Stretch-induced actomyosin contraction in epithelial tubes: Mechanotransduction pathways for tubular homeostasis

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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