Strategy of transcription regulation in the budding yeast

Sagi Levy, Jan Ihmels, Miri Carmi, Adina Weinberger, Gilgi Friedlander, Naama Barkai

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Cellular functionality is tightly coupled to the external environment. The type of nutrients available defines the internal metabolic flow, while their abundance often limits the rate of biomass production and energy available for growth. An abundance of toxins impede upon various aspects of cellular machinery, including metabolic capacity, protein stability or DNA integrity. Over evolutionary time scales, cells may encounter virtually endless environmental states at widely different frequencies. Maintaining optimal functionality in the presence of such external variability is a central evolutionary constraint.

Original languageEnglish
Title of host publicationInvestigations in Yeast Functional Genomics and Molecular Biology
Number of pages24
ISBN (Electronic)9781482240962
StatePublished - 1 Jan 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • General Medicine


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