Strategies for 1H-Detected Dynamic Nuclear Polarization Magic-Angle Spinning NMR Spectroscopy

Maria Concistré; Subhradip Paul; Marina Carravetta; Ilya Kuprov; Philip T.F. Williamson

doi:10.1002/chem.202003463

Strategies for ¹H-Detected Dynamic Nuclear Polarization Magic-Angle Spinning NMR Spectroscopy

Maria Concistré, Subhradip Paul, Marina Carravetta, Ilya Kuprov, Philip T.F. Williamson

Research output: Contribution to journal › Article › peer-review

Abstract

Combining dynamic nuclear polarization with proton detection significantly enhances the sensitivity of magic-angle spinning NMR spectroscopy. Herein, the feasibility of proton-detected experiments with slow (10 kHz) magic angle spinning was demonstrated. The improvement in sensitivity permits the acquisition of indirectly detected ¹⁴N NMR spectra allowing biomolecular structures to be characterized without recourse to isotope labelling. This provides a new tool for the structural characterization of environmental and medical samples, in which isotope labelling is frequently intractable.

Original language	English
Pages (from-to)	15852-15854
Number of pages	3
Journal	Chemistry - A European Journal
Volume	26
Issue number	68
DOIs	https://doi.org/10.1002/chem.202003463
State	Published - 4 Dec 2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Organic Chemistry

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10.1002/chem.202003463

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abstract = "Combining dynamic nuclear polarization with proton detection significantly enhances the sensitivity of magic-angle spinning NMR spectroscopy. Herein, the feasibility of proton-detected experiments with slow (10 kHz) magic angle spinning was demonstrated. The improvement in sensitivity permits the acquisition of indirectly detected 14N NMR spectra allowing biomolecular structures to be characterized without recourse to isotope labelling. This provides a new tool for the structural characterization of environmental and medical samples, in which isotope labelling is frequently intractable.",

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AU - Concistré, Maria

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AU - Kuprov, Ilya

AU - Williamson, Philip T.F.

PY - 2020/12/4

Y1 - 2020/12/4

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AB - Combining dynamic nuclear polarization with proton detection significantly enhances the sensitivity of magic-angle spinning NMR spectroscopy. Herein, the feasibility of proton-detected experiments with slow (10 kHz) magic angle spinning was demonstrated. The improvement in sensitivity permits the acquisition of indirectly detected 14N NMR spectra allowing biomolecular structures to be characterized without recourse to isotope labelling. This provides a new tool for the structural characterization of environmental and medical samples, in which isotope labelling is frequently intractable.

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M3 - مقالة

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SN - 0947-6539

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JO - Chemistry - A European Journal

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Strategies for ¹H-Detected Dynamic Nuclear Polarization Magic-Angle Spinning NMR Spectroscopy

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