Stimulation of epidermal hyperplasia and tumorigenesis by resident p16INK4a-expressing cells

Narmen Azazmeh; Ittai Ben-Porath

doi:10.1080/23723556.2020.1819752

Stimulation of epidermal hyperplasia and tumorigenesis by resident p16^INK4a-expressing cells

Narmen Azazmeh, Ittai Ben-Porath

Department of Developmental Biology and Cancer Research

The Hebrew University of Jerusalem

Research output: Contribution to journal › Comment/debate

Abstract

p16^INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16^INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16^INK4a in early epidermal lesions, which could potentially be targeted by senolytic therapy.

Original language	English
Article number	1819752
Journal	Molecular and Cellular Oncology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1080/23723556.2020.1819752
State	Published - 1 Nov 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CDKN2A
P16
Wnt
aging
epidermis
senescence

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

Access to Document

10.1080/23723556.2020.1819752

Cite this

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title = "Stimulation of epidermal hyperplasia and tumorigenesis by resident p16INK4a-expressing cells",

abstract = "p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16INK4a in early epidermal lesions, which could potentially be targeted by senolytic therapy.",

keywords = "CDKN2A, P16, Wnt, aging, epidermis, senescence",

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AB - p16INK4a (CDKN2A) is a central tumor-suppressor and activator of senescence. We recently found that prolonged expression of p16INK4a in epidermal cells induces hyperplasia and dysplasia through Wnt-mediated stimulation of neighboring keratinocytes. The study suggests a pro-tumorigenic function of p16INK4a in early epidermal lesions, which could potentially be targeted by senolytic therapy.

KW - CDKN2A

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