Abstract
Facile and modular access to stereodefined disubstituted aldehyde-derived silyl enol ethers allowed their successful application in a stereoselective aldol reaction affording the products with excellent yields and diastereomeric ratios. The counter-intuitive stereochemical behavior of this Mukaiyama-aldol reaction is accounted for by a non-classical open transition state.
Original language | English |
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Pages (from-to) | 12765-12769 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 60 |
Issue number | 23 |
DOIs | |
State | Published - 1 Jun 2021 |
Keywords
- Mukaiyama-aldol reaction
- acetals
- enolates
- scandium
- selectivity
All Science Journal Classification (ASJC) codes
- General Chemistry
- Catalysis