Stereoselective Preparation of CF3-Containing Cyclopropanes

Veronika Myronova; Dominique Cahard; Ilan Marek

doi:https://doi.org/10.1021/acs.orglett.2c03714

Stereoselective Preparation of CF₃-Containing Cyclopropanes

Veronika Myronova, Dominique Cahard, Ilan Marek

Chemistry

Technion - Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

Abstract

A regio- and diastereoselective carbometalation of easily accessible CF3-substituted cyclopropenes is developed with a diastereoselectivity of the addition opposite to the CF3 group. This simple strategy allows the preparation of polysubstituted (up to penta-) cyclopropyl rings possessing two adjacent quaternary carbon stereocenters with excellent diastereoselectivities.

Original language	English
Pages (from-to)	9076-9080
Number of pages	5
Journal	Organic Letters
Volume	24
Issue number	49
DOIs	https://doi.org/10.1021/acs.orglett.2c03714
State	Published - 16 Dec 2022

All Science Journal Classification (ASJC) codes

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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https://doi.org/10.1021/acs.orglett.2c03714

Cite this

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title = "Stereoselective Preparation of CF3-Containing Cyclopropanes",

abstract = "A regio- and diastereoselective carbometalation of easily accessible CF3-substituted cyclopropenes is developed with a diastereoselectivity of the addition opposite to the CF3 group. This simple strategy allows the preparation of polysubstituted (up to penta-) cyclopropyl rings possessing two adjacent quaternary carbon stereocenters with excellent diastereoselectivities.",

author = "Veronika Myronova and Dominique Cahard and Ilan Marek",

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doi = "https://doi.org/10.1021/acs.orglett.2c03714",

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T1 - Stereoselective Preparation of CF3-Containing Cyclopropanes

AU - Myronova, Veronika

AU - Cahard, Dominique

AU - Marek, Ilan

PY - 2022/12/16

Y1 - 2022/12/16

N2 - A regio- and diastereoselective carbometalation of easily accessible CF3-substituted cyclopropenes is developed with a diastereoselectivity of the addition opposite to the CF3 group. This simple strategy allows the preparation of polysubstituted (up to penta-) cyclopropyl rings possessing two adjacent quaternary carbon stereocenters with excellent diastereoselectivities.

AB - A regio- and diastereoselective carbometalation of easily accessible CF3-substituted cyclopropenes is developed with a diastereoselectivity of the addition opposite to the CF3 group. This simple strategy allows the preparation of polysubstituted (up to penta-) cyclopropyl rings possessing two adjacent quaternary carbon stereocenters with excellent diastereoselectivities.

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U2 - https://doi.org/10.1021/acs.orglett.2c03714

DO - https://doi.org/10.1021/acs.orglett.2c03714

M3 - مقالة

C2 - 36456393

SN - 1523-7060

VL - 24

SP - 9076

EP - 9080

JO - Organic Letters

JF - Organic Letters

IS - 49

ER -

Stereoselective Preparation of CF₃-Containing Cyclopropanes

Abstract

All Science Journal Classification (ASJC) codes

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