Stacking interactions by two Phe side chains stabilize and orient assemblies of even the minimal amphiphilic β-sheet motif

Zarzhitsky Shlomo; T. P. Vinod; Raz Jelinek; Hanna Rapaport

doi:10.1039/c4cc09673h

Stacking interactions by two Phe side chains stabilize and orient assemblies of even the minimal amphiphilic β-sheet motif

Zarzhitsky Shlomo, T. P. Vinod, Raz Jelinek, Hanna Rapaport

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Here we demonstrate that the smallest possible motif of the amphiphilic and pleated β-strand structure can be generated using tri-peptides stabilized by π-π stacking interactions. Monitoring the early stages of Phe-Glu-Phe fibril formation revealed unique angular orientations. Phe-Glu-Phe fibrils were further exploited as adsorbing templates for metal ions.

Original language	American English
Pages (from-to)	3154-3157
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	15
DOIs	https://doi.org/10.1039/c4cc09673h
State	Published - 21 Feb 2015

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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title = "Stacking interactions by two Phe side chains stabilize and orient assemblies of even the minimal amphiphilic β-sheet motif",

abstract = "Here we demonstrate that the smallest possible motif of the amphiphilic and pleated β-strand structure can be generated using tri-peptides stabilized by π-π stacking interactions. Monitoring the early stages of Phe-Glu-Phe fibril formation revealed unique angular orientations. Phe-Glu-Phe fibrils were further exploited as adsorbing templates for metal ions.",

author = "Zarzhitsky Shlomo and Vinod, \{T. P.\} and Raz Jelinek and Hanna Rapaport",

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AU - Shlomo, Zarzhitsky

AU - Vinod, T. P.

AU - Jelinek, Raz

AU - Rapaport, Hanna

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015/2/21

Y1 - 2015/2/21

N2 - Here we demonstrate that the smallest possible motif of the amphiphilic and pleated β-strand structure can be generated using tri-peptides stabilized by π-π stacking interactions. Monitoring the early stages of Phe-Glu-Phe fibril formation revealed unique angular orientations. Phe-Glu-Phe fibrils were further exploited as adsorbing templates for metal ions.

AB - Here we demonstrate that the smallest possible motif of the amphiphilic and pleated β-strand structure can be generated using tri-peptides stabilized by π-π stacking interactions. Monitoring the early stages of Phe-Glu-Phe fibril formation revealed unique angular orientations. Phe-Glu-Phe fibrils were further exploited as adsorbing templates for metal ions.

UR - http://www.scopus.com/inward/record.url?scp=84929999970&partnerID=8YFLogxK

U2 - 10.1039/c4cc09673h

DO - 10.1039/c4cc09673h

M3 - Article

C2 - 25604461

SN - 1359-7345

VL - 51

SP - 3154

EP - 3157

JO - Chemical Communications

JF - Chemical Communications

IS - 15

ER -

Stacking interactions by two Phe side chains stabilize and orient assemblies of even the minimal amphiphilic β-sheet motif

Abstract

All Science Journal Classification (ASJC) codes

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