TY - JOUR
T1 - Spontaneous and evoked activity patterns diverge over development
AU - Avitan, Lilach
AU - Pujic, Zac
AU - Mölter, Jan
AU - Zhu, Shuyu
AU - Sun, Biao
AU - Goodhill, Geoffrey J.
N1 - Funding Information: Imaging was performed at the Queensland Brain Institute’s Advanced Microscopy Facility using a Zeiss LSM 710 2-photon microscope, generously supported by the Australian Government through the ARC LIEF grant LE130100078. Publisher Copyright: © Avitan et al.
PY - 2021
Y1 - 2021
N2 - The immature brain is highly spontaneously active. Over development this activity must be integrated with emerging patterns of stimulus-evoked activity, but little is known about how this occurs. Here we investigated this question by recording spontaneous and evoked neural activity in the larval zebrafish tectum from 4 to 15 days post-fertilisation. Correlations within spontaneous and evoked activity epochs were comparable over development, and their neural assemblies refined in similar ways. However, both the similarity between evoked and spontaneous assemblies, and also the geometric distance between spontaneous and evoked patterns, decreased over development. At all stages of development, evoked activity was of higher dimension than spontaneous activity. Thus, spontaneous and evoked activity do not converge over development in this system, and these results do not support the hypothesis that spontaneous activity evolves to form a Bayesian prior for evoked activity.
AB - The immature brain is highly spontaneously active. Over development this activity must be integrated with emerging patterns of stimulus-evoked activity, but little is known about how this occurs. Here we investigated this question by recording spontaneous and evoked neural activity in the larval zebrafish tectum from 4 to 15 days post-fertilisation. Correlations within spontaneous and evoked activity epochs were comparable over development, and their neural assemblies refined in similar ways. However, both the similarity between evoked and spontaneous assemblies, and also the geometric distance between spontaneous and evoked patterns, decreased over development. At all stages of development, evoked activity was of higher dimension than spontaneous activity. Thus, spontaneous and evoked activity do not converge over development in this system, and these results do not support the hypothesis that spontaneous activity evolves to form a Bayesian prior for evoked activity.
UR - http://www.scopus.com/inward/record.url?scp=85105343661&partnerID=8YFLogxK
U2 - https://doi.org/10.7554/ELIFE.61942
DO - https://doi.org/10.7554/ELIFE.61942
M3 - Article
C2 - 33871351
SN - 2050-084X
VL - 10
JO - eLife
JF - eLife
M1 - e61942
ER -