Speed-stability paradox in DNA-scanning by zinc-finger proteins

Junji Iwahara; Yaakov Levy

doi:https://doi.org/10.4161/trns.23584

Speed-stability paradox in DNA-scanning by zinc-finger proteins

Junji Iwahara, Yaakov Levy

Department of Chemical and Structural Biology

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed.

Original language	English
Pages (from-to)	58-61
Number of pages	4
Journal	Transcription
Volume	4
Issue number	2
DOIs	https://doi.org/10.4161/trns.23584
State	Published - 1 Jan 2013

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Genetics

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abstract = "Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed. ",

author = "Junji Iwahara and Yaakov Levy",

note = "This work was supported by Grant 12BGIA8960032 from the American Heart Association (to J.I.), and Grant 2010424 from the US-Israel binational science foundation (to J.I and Y.L.). We thank Levani Zandarashvili, Dana Vuzman, and Alexandre Esadze for useful discussion.",

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AB - Extensive contact with DNA via multiple zinc fingers allows highly specific DNA-binding of zinc-finger-class transcription factors, but can also slow the target search process. Here we introduce recent insights into how zinc-finger proteins can rapidly scan DNA. Potential application of the new knowledge to the zinc-finger-based technology is also discussed.

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Speed-stability paradox in DNA-scanning by zinc-finger proteins

Abstract

All Science Journal Classification (ASJC) codes

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