Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

L. Pommarel; B. Vauzour; F. Megnin-Chanet; E. Bayart; O. Delmas; F. Goudjil; C. Nauraye; V. Letellier; F. Pouzoulet; F. Schillaci; F. Romano; V. Scuderi; G. A. P. Cirrone; E. Deutsch; A. Flacco; V. Malka

doi:10.1103/PhysRevAccelBeams.20.032801

Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

L. Pommarel, B. Vauzour, F. Megnin-Chanet, E. Bayart, O. Delmas, F. Goudjil, C. Nauraye, V. Letellier, F. Pouzoulet, F. Schillaci, F. Romano, V. Scuderi, G. A. P. Cirrone, E. Deutsch, A. Flacco, V. Malka

Research output: Contribution to journal › Article › peer-review

Abstract

The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system.

Original language	English
Article number	032801
Number of pages	10
Journal	Physical Review Accelerators and Beams
Volume	20
Issue number	3
DOIs	https://doi.org/10.1103/PhysRevAccelBeams.20.032801
State	Published - 2 Mar 2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

Nuclear and High Energy Physics
Surfaces and Interfaces
Physics and Astronomy (miscellaneous)

Access to Document

10.1103/PhysRevAccelBeams.20.032801License: CC BY

Cite this

Pommarel, L., Vauzour, B., Megnin-Chanet, F., Bayart, E., Delmas, O., Goudjil, F., Nauraye, C., Letellier, V., Pouzoulet, F., Schillaci, F., Romano, F., Scuderi, V., Cirrone, G. A. P., Deutsch, E., Flacco, A., & Malka, V. (2017). Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments. Physical Review Accelerators and Beams, 20(3), Article 032801. https://doi.org/10.1103/PhysRevAccelBeams.20.032801

@article{884932ddf947412c9547986d081832cd,

title = "Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments",

abstract = "The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system.",

author = "L. Pommarel and B. Vauzour and F. Megnin-Chanet and E. Bayart and O. Delmas and F. Goudjil and C. Nauraye and V. Letellier and F. Pouzoulet and F. Schillaci and F. Romano and V. Scuderi and Cirrone, {G. A. P.} and E. Deutsch and A. Flacco and V. Malka",

note = "The authors acknowledge the support of OSEO Project No. I0901001W-SAPHIR and of the European Research Council through the X-Five ERC project (Contract No. 339128). E. B. acknowledges support from the European Union{\textquoteright}s Horizon 2020 research and innovation program under Grant Agreement No. 654148 Laserlab-Europe.",

year = "2017",

month = mar,

day = "2",

doi = "10.1103/PhysRevAccelBeams.20.032801",

language = "الإنجليزيّة",

volume = "20",

journal = "Physical Review Accelerators and Beams",

issn = "2469-9888",

publisher = "American Physical Society",

number = "3",

}

Pommarel, L, Vauzour, B, Megnin-Chanet, F, Bayart, E, Delmas, O, Goudjil, F, Nauraye, C, Letellier, V, Pouzoulet, F, Schillaci, F, Romano, F, Scuderi, V, Cirrone, GAP, Deutsch, E, Flacco, A & Malka, V 2017, 'Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments', Physical Review Accelerators and Beams, vol. 20, no. 3, 032801. https://doi.org/10.1103/PhysRevAccelBeams.20.032801

TY - JOUR

T1 - Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

AU - Pommarel, L.

AU - Vauzour, B.

AU - Megnin-Chanet, F.

AU - Bayart, E.

AU - Delmas, O.

AU - Goudjil, F.

AU - Nauraye, C.

AU - Letellier, V.

AU - Pouzoulet, F.

AU - Schillaci, F.

AU - Romano, F.

AU - Scuderi, V.

AU - Cirrone, G. A. P.

AU - Deutsch, E.

AU - Flacco, A.

AU - Malka, V.

N1 - The authors acknowledge the support of OSEO Project No. I0901001W-SAPHIR and of the European Research Council through the X-Five ERC project (Contract No. 339128). E. B. acknowledges support from the European Union’s Horizon 2020 research and innovation program under Grant Agreement No. 654148 Laserlab-Europe.

PY - 2017/3/2

Y1 - 2017/3/2

N2 - The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system.

AB - The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system.

UR - http://www.scopus.com/inward/record.url?scp=85025465680&partnerID=8YFLogxK

U2 - 10.1103/PhysRevAccelBeams.20.032801

DO - 10.1103/PhysRevAccelBeams.20.032801

M3 - مقالة

SN - 2469-9888

VL - 20

JO - Physical Review Accelerators and Beams

JF - Physical Review Accelerators and Beams

IS - 3

M1 - 032801

ER -

Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this