Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Arya Biragyn; Milana Frenkel-Morgenstern; Orly Weissberg; Alessandro Gorohovski; Eugene Merzon; Ilan Green; Florencia Iulita; Lisi Flores-Aguilar; Mara Dierssen; Ilario De Toma; Hefziba Lifshitz; Stylianos E. Antonarakis; Eugene Yu; Yann Herault; Alexandra Botté; Randall Roper; Benjamin Sredni; Ronit Sarid; Jacqueline London; William Mobley; Andre Strydom; Eitan Okun; Tomer Illouz; Marie Claude Potier

doi:10.1007/s12017-021-08651-5

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Arya Biragyn, Milana Frenkel-Morgenstern, Orly Weissberg, Alessandro Gorohovski, Eugene Merzon, Ilan Green, Florencia Iulita, Lisi Flores-Aguilar, Mara Dierssen, Ilario De Toma, Hefziba Lifshitz, Stylianos E. Antonarakis, Eugene Yu, Yann Herault, Alexandra Botté, Randall Roper, Benjamin Sredni, Ronit Sarid, Jacqueline London, William MobleyAndre Strydom, Eitan Okun, Tomer Illouz, Marie Claude Potier

Bar-Ilan University, Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer’s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.

Original language	English
Pages (from-to)	561-571
Number of pages	11
Journal	NeuroMolecular Medicine
Volume	23
Issue number	4
DOIs	https://doi.org/10.1007/s12017-021-08651-5
State	Published - Dec 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
Down syndrome
Immune dysregulation
SARS-CoV-2
Vaccine

All Science Journal Classification (ASJC) codes

Neurology
Cellular and Molecular Neuroscience
Molecular Medicine

Access to Document

10.1007/s12017-021-08651-5

Cite this

Biragyn, A., Frenkel-Morgenstern, M., Weissberg, O., Gorohovski, A., Merzon, E., Green, I., Iulita, F., Flores-Aguilar, L., Dierssen, M., De Toma, I., Lifshitz, H., Antonarakis, S. E., Yu, E., Herault, Y., Botté, A., Roper, R., Sredni, B., Sarid, R., London, J., ... Potier, M. C. (2021). Specific Susceptibility to COVID-19 in Adults with Down Syndrome. NeuroMolecular Medicine, 23(4), 561-571. https://doi.org/10.1007/s12017-021-08651-5

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abstract = "The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer{\textquoteright}s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.",

keywords = "COVID-19, Down syndrome, Immune dysregulation, SARS-CoV-2, Vaccine",

author = "Arya Biragyn and Milana Frenkel-Morgenstern and Orly Weissberg and Alessandro Gorohovski and Eugene Merzon and Ilan Green and Florencia Iulita and Lisi Flores-Aguilar and Mara Dierssen and \{De Toma\}, Ilario and Hefziba Lifshitz and Antonarakis, \{Stylianos E.\} and Eugene Yu and Yann Herault and Alexandra Bott{\'e} and Randall Roper and Benjamin Sredni and Ronit Sarid and Jacqueline London and William Mobley and Andre Strydom and Eitan Okun and Tomer Illouz and Potier, \{Marie Claude\}",

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year = "2021",

month = dec,

doi = "10.1007/s12017-021-08651-5",

language = "الإنجليزيّة",

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Biragyn, A, Frenkel-Morgenstern, M, Weissberg, O, Gorohovski, A, Merzon, E, Green, I, Iulita, F, Flores-Aguilar, L, Dierssen, M, De Toma, I, Lifshitz, H, Antonarakis, SE, Yu, E, Herault, Y, Botté, A, Roper, R, Sredni, B, Sarid, R, London, J, Mobley, W, Strydom, A, Okun, E, Illouz, T & Potier, MC 2021, 'Specific Susceptibility to COVID-19 in Adults with Down Syndrome', NeuroMolecular Medicine, vol. 23, no. 4, pp. 561-571. https://doi.org/10.1007/s12017-021-08651-5

TY - JOUR

T1 - Specific Susceptibility to COVID-19 in Adults with Down Syndrome

AU - Biragyn, Arya

AU - Frenkel-Morgenstern, Milana

AU - Weissberg, Orly

AU - Gorohovski, Alessandro

AU - Merzon, Eugene

AU - Green, Ilan

AU - Iulita, Florencia

AU - Flores-Aguilar, Lisi

AU - Dierssen, Mara

AU - De Toma, Ilario

AU - Lifshitz, Hefziba

AU - Antonarakis, Stylianos E.

AU - Yu, Eugene

AU - Herault, Yann

AU - Botté, Alexandra

AU - Roper, Randall

AU - Sredni, Benjamin

AU - Sarid, Ronit

AU - London, Jacqueline

AU - Mobley, William

AU - Strydom, Andre

AU - Okun, Eitan

AU - Illouz, Tomer

AU - Potier, Marie Claude

PY - 2021/12

Y1 - 2021/12

N2 - The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer’s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.

AB - The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer’s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.

KW - COVID-19

KW - Down syndrome

KW - Immune dysregulation

KW - SARS-CoV-2

KW - Vaccine

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U2 - 10.1007/s12017-021-08651-5

DO - 10.1007/s12017-021-08651-5

M3 - مقالة

C2 - 33660221

SN - 1535-1084

VL - 23

SP - 561

EP - 571

JO - NeuroMolecular Medicine

JF - NeuroMolecular Medicine

IS - 4

ER -

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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