Spatiotemporal focal delivery of dual regenerating factors for osteochondral defect repair

Emil Ruvinov, Smadar Cohen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The design of focal spatiotemporal delivery systems for multiple regeneration-inducing factors represents a crucial step in the development of effective therapies for osteochondral injuries, osteoarthritis, and other pathologies of cartilage and bone. While endogenous bone regeneration is an established process, cartilage has very limited intrinsic regeneration ability. Thus, cartilage defects progressively affect subchondral bone and alter osteochondral interface homeostasis, leading to pain and disability. Spatiotemporal delivery of osteo- and chondroinductive factors by biomaterial-based systems represents an attractive therapeutic strategy for the currently available clinical therapies that still cannot provide a superior functional replacement for the damaged or lost tissue. This chapter offers an up-to-date review of the acellular biomaterial-based strategies, aimed at simultaneous regeneration of bone and cartilage by the controlled focal delivery of the appropriate factors. It describes the various factors and delivery systems (microspheres, hydrogels, and macroporous scaffolds) developed and tested in animals and presents a novel biomaterial approach, developed by our group, for the affinity binding of TGF-β1 and BMP-4 in two separate layers, which promoted the regeneration of osteochondral interface in rabbits with osteochondral defects.
Original languageAmerican English
Title of host publicationFocal Controlled Drug Delivery
EditorsA. Domb, W. Khan
Number of pages37
ISBN (Electronic)978-1-4614-9434-8
StatePublished - 2014

Publication series

NameAdvances in Delivery Science and Technology


  • Articular Cartilage
  • Autologous Chondrocyte Implantation
  • Cartilage Repair
  • Chondrogenic Differentiation
  • Subchondral Bone


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