Spatially constrained incoherent motion (SCIM) model improves quantitative diffusion-weighted MRI analysis of Crohn's disease patients

Vahid Taimouri, Moti Freiman, Onur Afacan, Simon K. Warfield

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Quantitative analysis of fast and slow diffusion from abdominal Diffusion-weighted MRI has the potential to provide important new insights into physiological and microstructural properties of the body. However, the commonly used, independent voxel-wise fitting of the signal decay model leads to imprecise parameter estimates, which has hampered their practical usage. In this work we evaluated the improvement in the precision of the fast and slow diffusion parameter estimates achieved by using a spatially-constrained Incoherent Motion (SCIM) model of DW-MRI signal decay in 5 healthy subjects and 24 Crohn's disease patients. We found that the improvement in Coefficient of Variation (CV) of the parameter estimates achieved using the SCIM model was significantly larger compared to thus achieved by repeated acquisition and signal averaging (n=5, paired Student's t-test, p ≤ 0.05). We also found that the SCIM model reduced the coefficient of variation of the parameter estimates of the D* and f parameter estimates in the ileum by 30% compared to the independent voxel-wise fitting of the signal decay model in the Crohn's patients data (n=24, paired Student's t-test, p ≤ 0.05). The SCIM model is more precise for quantitative analysis of abdominal DW-MRI signal decay.

Original languageEnglish
Title of host publicationAbdominal Imaging
Subtitle of host publicationComputation and Clinical Applications - 5th International Workshop, Held in Conjunction with MICCAI 2013, Proceedings
Pages11-19
Number of pages9
DOIs
StatePublished - 2013
Externally publishedYes
Event5th International Workshop on Abdominal Imaging: Computation and Clinical Applications, Held in Conjunction with 16th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2013 - Nagoya, Japan
Duration: 22 Sep 201322 Sep 2013

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8198 LNCS

Conference

Conference5th International Workshop on Abdominal Imaging: Computation and Clinical Applications, Held in Conjunction with 16th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2013
Country/TerritoryJapan
CityNagoya
Period22/09/1322/09/13

Keywords

  • Crohn's disease
  • Diffusion-weighted imaging
  • intra-voxel incoherent motion

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • General Computer Science

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