TY - JOUR
T1 - Spatial profiling technologies illuminate the tumor microenvironment
AU - Elhanani, Ofer
AU - Ben-Uri, Raz
AU - Keren, Leeat
N1 - We thank Dr. Idan Milo for scientific advice and assistance with preparation of figures. O.E. is supported by the Israel Cancer Research Foundation (ICRF) https://www.icrfonline.org/grants/. L.K. is supported by the Enoch foundation research fund, the Abisch-Frenkel Foundation, and grants funded by the Schwartz/Reisman Collaborative Science Program, European Research Council (94811), and the Israel Science Foundation (2481/20, 3830/21) within the Israel Precision Medicine Partnership program.
PY - 2023/3/13
Y1 - 2023/3/13
N2 - The tumor microenvironment (TME) is composed of many different cellular and acellular components that together drive tumor growth, invasion, metastasis, and response to therapies. Increasing realization of the significance of the TME in cancer biology has shifted cancer research from a cancer-centric model to one that considers the TME as a whole. Recent technological advancements in spatial profiling methodologies provide a systematic view and illuminate the physical localization of the components of the TME. In this review, we provide an overview of major spatial profiling technologies. We present the types of information that can be extracted from these data and describe their applications, findings and challenges in cancer research. Finally, we provide a future perspective of how spatial profiling could be integrated into cancer research to improve patient diagnosis, prognosis, stratification to treatment and development of novel therapeutics.
AB - The tumor microenvironment (TME) is composed of many different cellular and acellular components that together drive tumor growth, invasion, metastasis, and response to therapies. Increasing realization of the significance of the TME in cancer biology has shifted cancer research from a cancer-centric model to one that considers the TME as a whole. Recent technological advancements in spatial profiling methodologies provide a systematic view and illuminate the physical localization of the components of the TME. In this review, we provide an overview of major spatial profiling technologies. We present the types of information that can be extracted from these data and describe their applications, findings and challenges in cancer research. Finally, we provide a future perspective of how spatial profiling could be integrated into cancer research to improve patient diagnosis, prognosis, stratification to treatment and development of novel therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85150311815&partnerID=8YFLogxK
U2 - 10.1016/j.ccell.2023.01.010
DO - 10.1016/j.ccell.2023.01.010
M3 - مقالة مرجعية
C2 - 36800999
SN - 1535-6108
VL - 41
SP - 404
EP - 420
JO - Cancer Cell
JF - Cancer Cell
IS - 3
ER -