Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein

Muhammad Jbara; Mallikanti Seenaiah; Ashraf Brik

doi:10.1039/c4cc06499b

Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein

Muhammad Jbara
, Mallikanti Seenaiah
, Ashraf Brik

Department of Chemistry

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.

Original language	English
Pages (from-to)	12534-12537
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	83
DOIs	https://doi.org/10.1039/c4cc06499b
State	Published - 18 Sep 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c4cc06499b

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abstract = "Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.",

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AU - Jbara, Muhammad

AU - Seenaiah, Mallikanti

AU - Brik, Ashraf

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Y1 - 2014/9/18

N2 - Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.

AB - Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.

UR - https://www.scopus.com/pages/publications/84907821844

U2 - 10.1039/c4cc06499b

DO - 10.1039/c4cc06499b

M3 - Article

C2 - 25196573

SN - 1359-7345

VL - 50

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EP - 12537

JO - Chemical Communications

JF - Chemical Communications

IS - 83

ER -

Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein

Abstract

ASJC Scopus subject areas

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