Slip slidin' away of mitosis with CRL2Zyg11

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The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphasepromoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http ://dx .doi .org /10 .1083 /jcb .201601083) show that the E3 ligase CRL2ZYG11 degrades cyclin B1, allowing mitotic slippage.

Original languageAmerican English
Pages (from-to)143-145
Number of pages3
JournalJournal of Cell Biology
Issue number2
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Cell Biology


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