Sliding dynamics along DNA: a molecular perspective

Amir Marcovitz, Yaakov Levy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

DNA-binding proteins execute many different genetic tasks, such as transcription, repression, replication, and the repair of damaged DNA. Given the size of the genome, the large number of molecular species in vivo, and the crowded environment in which these processes take place, the remarkable efficiency and specificity of protein–DNA recognition present a major theoretical puzzle. In particular, two fundamental issues of great interest in protein– DNA recognition are: how proteins achieve a high degree of selectivity among a huge background of competing nonspecific DNA sequences and the aspect of the rapid recognition rate of the DNA target sequence by the protein.
Original languageEnglish
Title of host publicationInnovations in Biomolecular Modeling and Simulations
EditorsTamar Schlick
PublisherRoyal Society of Chemistry
Chapter10
Pages236-262
Number of pages27
Volume2
ISBN (Print)978-1-84973-462-2
StatePublished - 2012

Publication series

NameRSC Biomolecular Sciences

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • Molecular Biology
  • Biochemistry

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