SLAMF receptors on normal and malignant B cells

Idit Shachar; Avital Barak; Hadas Lewinsky; Lital Sever; Lihi Radomir

doi:10.1016/j.clim.2018.10.020

SLAMF receptors on normal and malignant B cells

Idit Shachar, Avital Barak, Hadas Lewinsky, Lital Sever, Lihi Radomir

Department of Systems Immunology

Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

Abstract

The Signaling Lymphocyte Activation Molecule family (SLAMF) is a collection of nine surface receptors expressed mainly on hematopoietic cells, and was found to modulate the behavior of immune cells. SLAMF receptors are expressed on B cells in health and disease. Each SLAM receptor has a unique differential expression pattern during the development and activation of B cells. Furthermore, recent findings have revealed a principal role for this family of receptors in B cell malignancies, emphasizing their importance in the control of malignant cell survival, cell to cell communication within the tumor microenvironment, retention in the supporting niches and regulation of T cell anti-tumor response. This review summarizes the latest studies regarding SLAMF expression and behavior in B cells and in B cell pathologies, and discusses the therapeutic potential of these receptors.

Original language	English
Pages (from-to)	23-30
Number of pages	8
Journal	Clinical Immunology
Volume	204
Early online date	15 Nov 2018
DOIs	https://doi.org/10.1016/j.clim.2018.10.020
State	Published - Jul 2019

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1016/j.clim.2018.10.020

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title = "SLAMF receptors on normal and malignant B cells",

abstract = "The Signaling Lymphocyte Activation Molecule family (SLAMF) is a collection of nine surface receptors expressed mainly on hematopoietic cells, and was found to modulate the behavior of immune cells. SLAMF receptors are expressed on B cells in health and disease. Each SLAM receptor has a unique differential expression pattern during the development and activation of B cells. Furthermore, recent findings have revealed a principal role for this family of receptors in B cell malignancies, emphasizing their importance in the control of malignant cell survival, cell to cell communication within the tumor microenvironment, retention in the supporting niches and regulation of T cell anti-tumor response. This review summarizes the latest studies regarding SLAMF expression and behavior in B cells and in B cell pathologies, and discusses the therapeutic potential of these receptors.",

author = "Idit Shachar and Avital Barak and Hadas Lewinsky and Lital Sever and Lihi Radomir",

note = "The authors wish to thank members of the Shachar lab for fruitful discussion and support. I.S. is the incumbent of the Dr. Morton and Ann Kleiman Professorial Chair. This research was supported by the DKFZ-MOST cooperation in cancer research, ERA-NET TRANSCAN-2 program JTC 2014–project FIRE-CLL, and the Binational Science Foundation (BSF) grant no 711979.",

year = "2019",

month = jul,

doi = "10.1016/j.clim.2018.10.020",

language = "الإنجليزيّة",

volume = "204",

pages = "23--30",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - SLAMF receptors on normal and malignant B cells

AU - Shachar, Idit

AU - Barak, Avital

AU - Lewinsky, Hadas

AU - Sever, Lital

AU - Radomir, Lihi

N1 - The authors wish to thank members of the Shachar lab for fruitful discussion and support. I.S. is the incumbent of the Dr. Morton and Ann Kleiman Professorial Chair. This research was supported by the DKFZ-MOST cooperation in cancer research, ERA-NET TRANSCAN-2 program JTC 2014–project FIRE-CLL, and the Binational Science Foundation (BSF) grant no 711979.

PY - 2019/7

Y1 - 2019/7

N2 - The Signaling Lymphocyte Activation Molecule family (SLAMF) is a collection of nine surface receptors expressed mainly on hematopoietic cells, and was found to modulate the behavior of immune cells. SLAMF receptors are expressed on B cells in health and disease. Each SLAM receptor has a unique differential expression pattern during the development and activation of B cells. Furthermore, recent findings have revealed a principal role for this family of receptors in B cell malignancies, emphasizing their importance in the control of malignant cell survival, cell to cell communication within the tumor microenvironment, retention in the supporting niches and regulation of T cell anti-tumor response. This review summarizes the latest studies regarding SLAMF expression and behavior in B cells and in B cell pathologies, and discusses the therapeutic potential of these receptors.

AB - The Signaling Lymphocyte Activation Molecule family (SLAMF) is a collection of nine surface receptors expressed mainly on hematopoietic cells, and was found to modulate the behavior of immune cells. SLAMF receptors are expressed on B cells in health and disease. Each SLAM receptor has a unique differential expression pattern during the development and activation of B cells. Furthermore, recent findings have revealed a principal role for this family of receptors in B cell malignancies, emphasizing their importance in the control of malignant cell survival, cell to cell communication within the tumor microenvironment, retention in the supporting niches and regulation of T cell anti-tumor response. This review summarizes the latest studies regarding SLAMF expression and behavior in B cells and in B cell pathologies, and discusses the therapeutic potential of these receptors.

U2 - 10.1016/j.clim.2018.10.020

DO - 10.1016/j.clim.2018.10.020

M3 - مقالة مرجعية

SN - 1521-6616

VL - 204

SP - 23

EP - 30

JO - Clinical Immunology

JF - Clinical Immunology

ER -

SLAMF receptors on normal and malignant B cells

Abstract

All Science Journal Classification (ASJC) codes

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