TY - JOUR
T1 - Single-Cell Genomics
T2 - A Stepping Stone for Future Immunology Discoveries
AU - Giladi, Amir
AU - Amit, Ido
N1 - I.A. is supported by the Chan Zuckerberg Initiative; the Howard Hughes Medical Institute International Scholar Award; European Research Council Consolidator Grant 724471-HemTree2.0; a Melanoma Research Alliance Established Investigator Award (509044); the Israel Science Foundation (703/15); the Ernest and Bonnie Beutler Research Program of Excellence in Genomic Medicine; the Helen and Martin Kimmel Award for Innovative Investigation; a Minerva Stiftung research grant; the Israeli Ministry of Science, Technology, and Space; the David and Fela Shapell Family Foundation; the NeuroMac DFG (German Research Foundation)/Transregional Collaborative Research Center Grant; and the Abramson Family Center for Young Scientists. The authors declare patent applications relating to several parts of this Perspective.
PY - 2018/1/11
Y1 - 2018/1/11
N2 - The immunology field has invested great efforts and ingenuity to characterize the various immune cell types and elucidate their functions. However, accumulating evidence indicates that current technologies and classification schemes are limited in their ability to account for the functional heterogeneity of immune processes. Single-cell genomics hold the potential to revolutionize the way we characterize complex immune cell assemblies and study their spatial organization, dynamics, clonal distribution, pathways, function, and crosstalks. In this Perspective, we consider recent and forthcoming technological and analytical advances in single-cell genomics and the potential impact of those advances on the future of immunology research and immunotherapy.
AB - The immunology field has invested great efforts and ingenuity to characterize the various immune cell types and elucidate their functions. However, accumulating evidence indicates that current technologies and classification schemes are limited in their ability to account for the functional heterogeneity of immune processes. Single-cell genomics hold the potential to revolutionize the way we characterize complex immune cell assemblies and study their spatial organization, dynamics, clonal distribution, pathways, function, and crosstalks. In this Perspective, we consider recent and forthcoming technological and analytical advances in single-cell genomics and the potential impact of those advances on the future of immunology research and immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=85041115553&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.cell.2017.11.011
DO - https://doi.org/10.1016/j.cell.2017.11.011
M3 - مقالة مرجعية
SN - 0092-8674
VL - 172
SP - 14
EP - 21
JO - Cell
JF - Cell
IS - 1-2
ER -