@inbook{7a526b965dec45e5ab37c3faf8e67f2d,
title = "Simultaneous Mapping of Enhancers and Enhancer Rearrangements with Paired-End H3K27ac ChIP-seq",
abstract = "We describe a protocol for H3K27ac ChIP paired-end sequencing and computational analysis of rearrangements. Our approach can be used to simultaneously map enhancers and their activity and to identify structural variations at enhancers. Since changes in enhancer activity and new enhancer translocations both play a major role in tumor initiation, progression, and response to therapy, this approach holds promise to uncover some of the mechanisms behind these processes.",
keywords = "ChIP-seq, Enhancer rearrangements, Histone modifications, Structural variation",
author = "Israel Antman and Ester Davis and Shahd Abu-Kamel and Merav Hecht and Yotam Drier",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2022",
doi = "https://doi.org/10.1007/978-1-0716-2513-2_11",
language = "الإنجليزيّة",
series = "Methods in Molecular Biology",
pages = "131--140",
booktitle = "Methods in Molecular Biology",
}