Silk protein structures

Tuomas P. J. Knowles (Inventor), Ulyana Shimanovich (Inventor), Chris Holland (Inventor)

Research output: Patent


The present invention provides a capsule having a shell of material that comprises an assembly of a silk protein, such as an assembly that is a non-aggregated assembly of the silk protein, such as an assembly where the a-helix, β-sheet (native) and random coil content is at least 55%. Also provided are methods for preparing the capsule, which comprises the step of contacting a flow of a first phase and a flow of a second phase in a channel, thereby to generate in the channel a dispersion of discrete regions, preferably droplets, of the second phase in the first phase, wherein the second phase comprises a silk protein suitable for forming an assembly of a protein, thereby to form a capsule shell at the boundary of the discrete region, wherein the first and second phases are immiscible.
Original languageEnglish
Patent numberWO2016034730A1
Priority date9/09/14
Filing date4/09/15
StatePublished - 10 Mar 2016
Externally publishedYes


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