Signaling by antibodies: Recent progress

Stylianos Bournazos; Taia T. Wang; Rony Dahan; Jad Maamary; Jeffrey V. Ravetch

doi:https://doi.org/10.1146/annurev-immunol-051116-052433

Signaling by antibodies: Recent progress

Stylianos Bournazos, Taia T. Wang, Rony Dahan, Jad Maamary, Jeffrey V. Ravetch

Department of Systems Immunology

Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

Abstract

IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.

Original language	English
Pages (from-to)	285-311
Number of pages	27
Journal	ANNUAL REVIEW OF IMMUNOLOGY
Volume	35
DOIs	https://doi.org/10.1146/annurev-immunol-051116-052433
State	Published - 26 Apr 2017

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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abstract = "IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.",

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AU - Ravetch, Jeffrey V.

PY - 2017/4/26

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N2 - IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.

AB - IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.

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DO - https://doi.org/10.1146/annurev-immunol-051116-052433

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EP - 311

JO - ANNUAL REVIEW OF IMMUNOLOGY

JF - ANNUAL REVIEW OF IMMUNOLOGY

ER -

Signaling by antibodies: Recent progress

Abstract

All Science Journal Classification (ASJC) codes

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