Shearing of surface mucin saps tumor cell strength

Liza J. Greenberg; Deborah Fass

doi:10.1016/j.tips.2023.08.011

Shearing of surface mucin saps tumor cell strength

Liza J. Greenberg, Deborah Fass

Department of Chemical and Structural Biology

Weizmann Institute of Science

Research output: Contribution to journal › Short survey › peer-review

Abstract

Aberrant expression of transmem-brane mucins promotes tumor progression and interferes with im-munological and medicinal elimina-tion of cancer cells. In a recent article, Pedram et al. directed an at-tenuated bacterial mucin-specific protease to HER2-positive tumor cells and observed decreased tumor growth rates and extended survival of mice bearing HER2-positive tumors.

Original language	English
Pages (from-to)	755-757
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	44
Issue number	11
Early online date	5 Sep 2023
DOIs	https://doi.org/10.1016/j.tips.2023.08.011
State	Published - Nov 2023

All Science Journal Classification (ASJC) codes

Toxicology
Pharmacology

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title = "Shearing of surface mucin saps tumor cell strength",

abstract = "Aberrant expression of transmem-brane mucins promotes tumor progression and interferes with im-munological and medicinal elimina-tion of cancer cells. In a recent article, Pedram et al. directed an at-tenuated bacterial mucin-specific protease to HER2-positive tumor cells and observed decreased tumor growth rates and extended survival of mice bearing HER2-positive tumors.",

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year = "2023",

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AU - Fass, Deborah

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AB - Aberrant expression of transmem-brane mucins promotes tumor progression and interferes with im-munological and medicinal elimina-tion of cancer cells. In a recent article, Pedram et al. directed an at-tenuated bacterial mucin-specific protease to HER2-positive tumor cells and observed decreased tumor growth rates and extended survival of mice bearing HER2-positive tumors.

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Shearing of surface mucin saps tumor cell strength

Abstract

All Science Journal Classification (ASJC) codes

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