Shearing of surface mucin saps tumor cell strength

Liza J. Greenberg; Deborah Fass

doi:10.1016/j.tips.2023.08.011

Shearing of surface mucin saps tumor cell strength

Liza J. Greenberg, Deborah Fass

Department of Chemical and Structural Biology

Weizmann Institute of Science

Research output: Contribution to journal › Short survey › peer-review

Abstract

Aberrant expression of transmem-brane mucins promotes tumor progression and interferes with im-munological and medicinal elimina-tion of cancer cells. In a recent article, Pedram et al. directed an at-tenuated bacterial mucin-specific protease to HER2-positive tumor cells and observed decreased tumor growth rates and extended survival of mice bearing HER2-positive tumors.

Original language	English
Pages (from-to)	755-757
Number of pages	3
Journal	Trends in Pharmacological Sciences
Volume	44
Issue number	11
Early online date	5 Sep 2023
DOIs	https://doi.org/10.1016/j.tips.2023.08.011
State	Published - Nov 2023

All Science Journal Classification (ASJC) codes

Toxicology
Pharmacology

Access to Document

10.1016/j.tips.2023.08.011License: CC BY

https://harvester-2-eu.services.rm.elsevier.com/ws/6ced8d3b-d9ff-4f31-979a-0647230ba9f4/1815c317-615c-4123-822c-c2c538e6ff99/ws/files/113219669/df_TrendsPharmacolSci_ShearingofSurfaceMucin_PV_2023.pdfLicense: CC BY

Cite this

@article{9d961b2026f84de1a850d65e2916cffe,

title = "Shearing of surface mucin saps tumor cell strength",

abstract = "Aberrant expression of transmem-brane mucins promotes tumor progression and interferes with im-munological and medicinal elimina-tion of cancer cells. In a recent article, Pedram et al. directed an at-tenuated bacterial mucin-specific protease to HER2-positive tumor cells and observed decreased tumor growth rates and extended survival of mice bearing HER2-positive tumors.",

author = "Greenberg, {Liza J.} and Deborah Fass",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = nov,

doi = "10.1016/j.tips.2023.08.011",

language = "الإنجليزيّة",

volume = "44",

pages = "755--757",

journal = "Trends in Pharmacological Sciences",

issn = "0165-6147",

publisher = "Elsevier Ltd.",

number = "11",

}

TY - JOUR

T1 - Shearing of surface mucin saps tumor cell strength

AU - Greenberg, Liza J.

AU - Fass, Deborah

PY - 2023/11

Y1 - 2023/11

N2 - Aberrant expression of transmem-brane mucins promotes tumor progression and interferes with im-munological and medicinal elimina-tion of cancer cells. In a recent article, Pedram et al. directed an at-tenuated bacterial mucin-specific protease to HER2-positive tumor cells and observed decreased tumor growth rates and extended survival of mice bearing HER2-positive tumors.

AB - Aberrant expression of transmem-brane mucins promotes tumor progression and interferes with im-munological and medicinal elimina-tion of cancer cells. In a recent article, Pedram et al. directed an at-tenuated bacterial mucin-specific protease to HER2-positive tumor cells and observed decreased tumor growth rates and extended survival of mice bearing HER2-positive tumors.

UR - http://www.scopus.com/inward/record.url?scp=85171276145&partnerID=8YFLogxK

U2 - 10.1016/j.tips.2023.08.011

DO - 10.1016/j.tips.2023.08.011

M3 - عرض مختصر

C2 - 37679271

SN - 0165-6147

VL - 44

SP - 755

EP - 757

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 11

ER -

Shearing of surface mucin saps tumor cell strength

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this