When people engage in moral discourse, this involves questioning and rationalizing underlying assumptions. Qualitative analysis of these shared questions and assumptions can lead to their underpinning “cultural scripts”. We describe this methodology in the context of focus group discussions as a form of “mini” public discourse. By examining lay, affected, and religious groups in Germany and Israel, we aim to study how cultural (national and religious) contrasts exist alongside shared positions. The latter point us to the necessary reflection about what ‘being affected’ by disease-based experiences means for bioethics.